Contribution of Hla-B51 in the susceptibility and specific clinical features of Behcet's disease in Tunisian patients

European Journal of Internal Medicine
Amira HamzaouiM Miled

Abstract

Many researchers have tried to investigate the association of HLA-B51 with the severity and the clinical features of BD with conflicting results. We aimed at investigating the association of HLA-B51 with demographical and clinical manifestations as well as the severity of BD, by studying 178 native Tunisian BD patients, fulfilling the International Study group criteria for the BD classification recruited from the Department of Internal Medicine, Rabta Hospital in Tunis and compared with 125 native Tunisian healthy age and sex matching volunteers. According to our findings, the frequency of HLAB 51 was significantly higher in BD patients than in controls (p<0.001). Positive pathergy test (PPT) (p = 0.01) and retinal vasculitis (p = 0.045), were significantly more frequent in HLA B51(+) patients, while the frequency of arterial aneurysms (p = 0.009) and neurological involvement, especially the parenchymal involvement (p<0.001), were significantly and clearly higher in HLA B51(-) patients. The patients without HLA B51 had a significantly less severe disease (p = 0.001). Discussion/conclusion We conclude that HLA B51 is a predisposing marker for BD in our population as in most ethnic groups. It seems to be associated with a subgrou...Continue Reading

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Citations

Aug 13, 2013·Journal français d'ophtalmologie·A ChebilL El Matri
Nov 12, 2013·La Revue de médecine interne·M H Houman, N Bel Feki
Jun 29, 2014·Clinical Pediatrics·Robert M Burkes, Nasreen A Bhumbra
Mar 31, 2018·Inflammopharmacology·Fatmazohra Djaballah-IderChafia Touil-Boukoffa
Jan 12, 2017·The Korean Journal of Internal Medicine·Hee Jung RyuHan Joo Baek
Aug 3, 2018·The Open Rheumatology Journal·Yan DengXiaodong Zhou
Jan 11, 2020·Frontiers in Immunology·Erkan DemirkayaIvona Aksentijevich
Nov 2, 2019·Multiple Sclerosis and Related Disorders·Paula WildnerMariola Matysiak
Jan 10, 2021·Clinical and Experimental Immunology·M ElfishawiS Elfishawi
Jul 20, 2020·Current Drug Targets·Jermilia CharlesVictoria A Ploplis

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