Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria

Journal of Innate Immunity
Ulrike BinskerSven Hammerschmidt

Abstract

A successful colonization of different compartments of the human host requires multifactorial contacts between bacterial surface proteins and host factors. Extracellular matrix proteins and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia. Human platelets secrete thrombospondin-1, which is then acquired by invading pathogens to facilitate colonization and immune evasion. Gram-positive bacteria express a broad spectrum of surface-exposed proteins, some of which also recognize thrombospondin-1. This review highlights the importance of thrombospondin-1 as an adhesion substrate to facilitate colonization, and we summarize the variety of thrombospondin-1-binding proteins of S. pneumoniae and S. aureus.

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Citations

Jan 9, 2021·Journal of Cell Communication and Signaling·Sukhbir Kaur, David D Roberts
Jul 9, 2021·Frontiers in Cardiovascular Medicine·Gaukhar BaidildinovaPaola E J van der Meijden
Jun 6, 2019·Journal of Innate Immunity·Arne Egesten, Heiko Herwald

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