PMID: 9427111Jan 14, 1998Paper

Contribution of humoral systems to the recovery of blood pressure following severe haemorrhage

Journal of Autonomic Pharmacology
P Ponchon, J L Elghozi

Abstract

1. Profound haemorrhage activates a number of pressor mechanisms, including the release of catecholamines, angiotensin II and arginine-vasopressin, which contribute to the subsequent cardiovascular recovery. Using specific single or combined blockade with prazosin, losartan and Manning compound (AVPX), the aim of this study was to evaluate the involvement of the three pressor systems in blood pressure recovery following severe haemorrhage (20 ml kg-1). 2. Haemorrhage of conscious, unrestrained rats resulted in a significant initial decrease in blood pressure of approximately 60 mmHg, and heart rate of approximately 70 bpm. Then, blood pressure tended to return to the control level within 10 min. The total cardiovascular recovery corresponded to increments of 52 +/- 5 mmHg (81% of the acute fall) for systolic blood pressure, and of 92 +/- 22 bpm (124%) for heart rate at 60 min post-bleeding. Significant falls in haematocrit (-10.5 +/- 1.2%, P < 0.01), in plasma concentrations of proteins (-10.3 +/- 0.9 g l-1, P < 0.01) and haemoglobin (-2.58 +/- 0.72 g 100 ml-1, P < 0.05) were observed at 60 min post-bleeding. 3. Pretreatment with one or two specific antagonists did not exaggerate the initial fall in blood pressure. The initial ...Continue Reading

Citations

Jul 4, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A GirardJ L Elghozi
Nov 4, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Facundo Martín BerteraChristian Höcht
Jun 30, 2011·The Journal of Physiological Sciences : JPS·Takahiko YoshimotoTakao Kumazawa
Dec 9, 2008·Autonomic Neuroscience : Basic & Clinical·Cristiane BusnardoFernando Morgan Aguiar Corrêa
Oct 29, 2005·The American Journal of Cardiology·Sunil V RaoRobert A Harrington
Sep 26, 2007·Journal of Neuroscience Research·Gislaine Garcia PelosiFernando Morgan Aguiar Corrêa
Apr 1, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martha L Blair, Deanne Mickelsen

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