PMID: 8466911Apr 13, 1993Paper

Contribution of hydrogen bonding to lipid-lipid interactions in membranes and the role of lipid order: effects of cholesterol, increased phospholipid unsaturation, and ethanol

Biochemistry
S J SlaterC D Stubbs

Abstract

It is proposed that increased phospholipid unsaturation in membranes and perturbation by agents such as ethanol weaken interlipid hydrogen bonding involving water and that the process is independent of effects on lipid order. To investigate this, the rates of phospholipid desorption, as a measure of the strength of interlipid interactions, from "donor" lipid vesicles was determined. This was accomplished using (7-nitrobenzo-2-oxa-1,3-diazole-4-yl)aminohexanoate (C6-NBD) labeled phospholipids, the rate of desorption being followed from changes in fluorescence with time. The rates of desorption of the NBD-phospholipids from phosphatidylcholine (PC) donor vesicles was in the order phosphatidylcholine (PC) > phosphatidylserine (PS) > phosphatidylethanolamine (PE), the slower rates in the PS and PE reflecting direct interlipid hydrogen bonding. For PC, the interlipid hydrogen bonding was restricted to the "hydration layer", the network of hydrogen-bonded water molecules extending between phospholipid head groups. The rate of C6-NBD-PC desorption was elevated with higher levels of donor PC sn-2 unsaturation, due the increased head group spacing weakening the lipid-lipid interactions that occur via the hydration layer. Ethanol also in...Continue Reading

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Citations

Mar 1, 1995·Journal of Fluorescence·C D StubbsS J Slater
Oct 30, 2012·Cell Biochemistry and Biophysics·Monika Naumowicz, Zbigniew Artur Figaszewski
Jul 15, 1996·Chemistry and Physics of Lipids·C D Stubbs, S J Slater
Mar 1, 1996·Alcohol·W R Klemm, H J Williams
Feb 25, 2003·Chemistry and Physics of Lipids·Amitabha Chattopadhyay
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Aug 22, 2009·Toxicology Mechanisms and Methods·Barbara Szachowicz-PetelskaZbigniew A Figaszewski
Jan 31, 2016·Biochimica Et Biophysica Acta·Marta Pasenkiewicz-GierulaKrzysztof Murzyn
Jun 7, 2011·Steroids·Monika NaumowiczZbigniew Artur Figaszewski
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May 12, 2016·Physical Chemistry Chemical Physics : PCCP·Sai J GanesanSilvina Matysiak
Jun 9, 2016·Biochimica Et Biophysica Acta·Pauline LoisonMarina K Kuimova

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