Abstract
The spontaneously diabetic torii (SDT) fatty rat is a new model of type 2 diabetes showing overt obesity, hyperglycemia and hyperlipidemia. With early onset of diabetes mellitus, diabetic microvascular complications, including nephropathy, peripheral neuropathy and retinopathy, are observed at young ages. In the present study, blood glucose levels of female SDT fatty rats were controlled with phlorizin, a non-selective SGLT inhibitor, to examine whether and how these complications are caused by hyperglycemia. Phlorizin treatment adequately controlled plasma glucose levels during the experiment. At 29 weeks of age, urinary albumin excretion considerably increased in SDT fatty rats. Glomerulosclerosis and tubular pathological findings also indicate diabetic nephropathy. These renal parameters tended to decrease with phlorizin; however, effects were partial. Sciatic nerve conduction velocities were significantly delayed in SDT fatty rats compared with Sprague-Dawley (SD) rats. Intraepidermal nerve fiber density, an indicator of subclinical small nerve fiber neuropathy, significantly decreased in SDT fatty rats. Retinal dysfunction (prolongation of peak latency for oscillatory potential in electroretinograms) and histopathological ...Continue Reading
References
Jul 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C GuijarroW F Keane
Aug 3, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C Y HsuG C Curhan
Oct 27, 2001·Diabetes·J S HarmonR P Robertson
Mar 5, 2002·The Journal of Biological Chemistry·Lijun SunMoshe Levi
May 7, 2004·Brain : a Journal of Neurology·Chia-Tung ShunSung-Tsang Hsieh
Dec 30, 2004·Diabetes/metabolism Research and Reviews·Joel R L EhrenkranzJesse Roth
Feb 24, 2005·Experimental Animals·Taku MasuyamaMasami Shinohara
Aug 22, 2006·Diabetes, Obesity & Metabolism·T SasaseM Matsushita
Oct 14, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M HorstinkUNKNOWN Movement Disorder Society-European Section
Jul 14, 2007·Diabetes·Irina G ObrosovaViktor R Drel
Mar 12, 2008·Diabetes·Valentine BrusseeDouglas W Zochodne
Apr 19, 2008·Experimental Animals·Kenichi MatsuiMutsuyoshi Matsushita
Sep 5, 2008·Experimental Diabetes Research·Slava MalatialiMario Barac-Nieto
Nov 11, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Muhammad A Abdul-Ghani, Ralph A DeFronzo
Nov 26, 2008·Hypertension·Andrey C da Costa GoncalvesVolkmar Gross
Jul 21, 2009·Diabetes, Obesity & Metabolism·T SasaseA Kakehashi
Mar 13, 2010·Experimental Animals·Yukihito IshiiMutsuyoshi Matsushita
Jul 1, 2010·The New England Journal of Medicine·UNKNOWN ACCORD Study GroupLawrence J Fine
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·UNKNOWN Joint Task Force of the EFNS and the PNS
Jul 28, 2010·Experimental Animals·Yukihito IshiiTakeshi Ohta
Dec 4, 2010·The Journal of Veterinary Medical Science·Yukihito IshiiTakeshi Ohta
Aug 4, 2011·Diabetes·Tatsuhito HimenoJiro Nakamura
Aug 2, 2012·The Journal of Veterinary Medical Science·Takayuki YamaguchiMutsuyoshi Matsushita
Dec 12, 2012·Oxidative Medicine and Cellular Longevity·Horacio OsorioBruno Escalante
May 22, 2013·Journal of Diabetes Research·Yusuke KemmochiTakeshi Ohta
Apr 29, 2014·Experimental Animals·Yoshiaki KatsudaTakahisa Yamada
Jun 4, 2014·Journal of Diabetes Research·Takeshi OhtaTakahisa Yamada
Sep 30, 2014·Diabetes Research and Clinical Practice·Eri MukaiTakashi Miki
Citations
May 15, 2018·Clinical and Experimental Pharmacology & Physiology·Katsuya SakimuraTakeshi Ohta
Mar 13, 2018·Physiological Research·Y MotohashiT Ohta
Aug 7, 2019·Pharmacology Research & Perspectives·Paul OranjeGerard J P van Westen
Oct 23, 2019·Journal of Diabetes Research·Yoshiaki TanakaAkihiro Kakehashi
Sep 8, 2020·Bioscience, Biotechnology, and Biochemistry·Yan WangWei Chen
Jul 18, 2018·The Journal of Veterinary Medical Science·Tatsuya MaekawaShinichi Kume
Jun 2, 2018·BioMed Research International·Jéssica P Álvarez-RendónJuan R Riesgo-Escovar
Oct 23, 2018·International Journal of Endocrinology·Katsuya SakimuraTakeshi Ohta
Oct 9, 2020·Critical Reviews in Food Science and Nutrition·Ao ShangRen-You Gan
Feb 11, 2021·Food & Function·Yaojie LiuHao Wang
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie ZhangQingsong Jiang
Jan 18, 2021·Physiological Research·R SanoT Ohta
Apr 13, 2021·Food Science & Nutrition·Wei ZhangJuchun Lin
May 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tsukasa NozuToshikatsu Okumura