Contribution of immunology to implantation failure of euploid embryos

Fertility and Sterility
Jason M Franasiak, Richard T Scott

Abstract

Outcomes in assisted reproduction have seen marked improvement. With increased ability in the embryology laboratory to use extended embryo culture which in turn enables other selective techniques, such as trophectoderm biopsy and comprehensive chromosome screening, the chance of success per embryo transfer is increased. However, even the selection of a euploid blastocyst, which selects out many embryonic factors, does not yield successful implantation and ultimately delivery in all cases. Among the factors that affect implantation failure of apparently reproductively competent embryos, the immune system has been perhaps both the most plausible and the most debated. There are data on T-helper cells, in particular the TH1-TH2 balance, peripheral and uterine natural killer cells, and autoantibodies, all of which have been shown to have variable effects on implantation. Many investigators have developed and used a wide range of immune tests and treatments aimed at manipulating the milieu to favor implantation. Although it is certain that the immune system plays a role in implantation, our understanding of the physiology, let alone the pathophysiology, remains incomplete. It is imperative that we gain more clear evidence of causes a...Continue Reading

Citations

Dec 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Margareta D PisarskaErica T Wang
Jun 20, 2019·International Journal of Molecular Sciences·Clara ApicellaDaniel Vaiman
Apr 6, 2020·American Journal of Reproductive Immunology : AJRI·Marcelo Borges CavalcanteRicardo Barini
Apr 7, 2020·Current Opinion in Obstetrics & Gynecology·Yigit Cakiroglu, Bulent Tiras
Jul 24, 2020·Regenerative Medicine·Fusanori YotsumotoShingo Miyamoto
Mar 9, 2019·Journal of Assisted Reproduction and Genetics·Kevin Marron, Conor Harrity
Sep 9, 2018·Journal of Assisted Reproduction and Genetics·Kevin MarronConor Harrity
Jan 10, 2021·International Journal of Molecular Sciences·Griselda A Cabral-PachecoMargarita L Martinez-Fierro
Feb 22, 2021·Fertility and Sterility·Diana AlecsandruJason M Franasiak
Aug 4, 2020·Journal of Translational Autoimmunity·Torie C PlowdenSunni L Mumford
May 16, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Yusuf Aytac TohmaHulusi Bulent Zeyneloglu

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