Contribution of infection to increased mortality in women after cardiac surgery

Archives of Internal Medicine
Mary A M RogersSanjay Saint

Abstract

Women have higher mortality rates after coronary artery bypass graft (CABG) surgery compared with men. Explanations for this sex difference are controversial. The objective of this study was to assess whether infection contributes to the increased risk of mortality in women. We conducted a cohort study of 9218 Michigan Medicare beneficiaries hospitalized for CABG surgery. The prevalence of infection at any site during hospitalization was determined. Patients were followed up for 100 days after surgery to assess vital status. Analyses were conducted using proportional hazards regression and population attributable risk. Women hospitalized for CABG surgery were more likely to have an infection than men (16.1% vs 9.8%, P<.001), regardless of age, race, type of admission, hospital volume, or presence of comorbidities. Infections of the respiratory tract, urinary tract, digestive tract, and skin and subcutaneous tissue were more common in women than in men. The risk of death in men increased 3-fold with infection, whereas the risk in women increased 1.8-fold. The interaction between infection and sex on mortality was significant after adjusting for age, type of admission, and presence of comorbidities (P = .008). The unadjusted perc...Continue Reading

Citations

Nov 22, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Michael C ChristensenChristian von Heymann
Mar 5, 2015·European Journal of Preventive Cardiology·Marcassa ClaudioGiannuzzi Pantaleo
Sep 14, 2016·The Journal of Surgical Research·Courtney J PokrzywaGregory D Kennedy
Oct 14, 2008·Qualitative Health Research·Sheila A Turris, Joy L Johnson
Jul 16, 2009·Critical Care Medicine·Alain CombesJean Chastre
May 25, 2007·Critical Care Medicine·Anthony F Suffredini
Sep 1, 2015·The Annals of Thoracic Surgery·Donald S LikoskyUNKNOWN Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative

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