PMID: 12757568May 22, 2003Paper

Contribution of informant and patient ratings to the accuracy of the mini-mental state examination in predicting probable Alzheimer's disease

Journal of the American Geriatrics Society
Mary C TierneyJohn P Szalai

Abstract

To determine whether the accuracy of the Mini-Mental State Examination (MMSE) in predicting future Alzheimer's disease (AD) could be improved by the addition of patient and informant ratings of cognitive difficulties. An inception cohort of nondemented patients followed longitudinally for 2 years. Patients referred to a university teaching hospital research investigation by their family physicians because of concerns about memory impairment. One hundred sixty-five community-residing patients were included who did not have dementia or any identifiable cause for memory impairment. After 2 years, 29 met criteria for AD, and 95 were not demented. Baseline assessments included MMSE, an Informant Rating Scale, and a Patient Rating Scale of cognitive difficulties. After 2 years, patients were diagnosed following the reference standard for probable AD. Diagnosticians were blind to baseline scores. Age and education were included in all analyses as covariates. The best logistic regression model included the Informant Rating Scale and the MMSE (sensitivity = 83%, specificity = 79%). An empirically reduced six-item model that included two items each from the MMSE, the Patient Rating Scale, and the Informant Rating Scale produced a signifi...Continue Reading

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Citations

Jun 9, 2005·Alzheimer Disease and Associated Disorders·John C Morris
Jun 5, 2007·Alzheimer Disease and Associated Disorders·Hilary A ArcherMartin N Rossor
Apr 2, 2005·Dementia and Geriatric Cognitive Disorders·E KalbeK Herholz
Apr 1, 2006·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·J Wesson AshfordHerman Buschke
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Jan 31, 2012·Dementia and Geriatric Cognitive Disorders·Haiqun XieLisa Koski
Jun 28, 2006·International Journal of Geriatric Psychiatry·Jianzhao ShenKathleen S Hall
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Oct 20, 2019·Alzheimer's Research & Therapy·Mary M RyanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 12, 2005·Clinical Trials : Journal of the Society for Clinical Trials·Richard B ScottKatherine Carpenter
Oct 6, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Jennifer Heidler-Gary, Argye E Hillis
May 22, 2003·Journal of the American Geriatrics Society·Anthony F Jorm
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
Aug 24, 2005·Neurology·J E GalvinJ C Morris

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