Contribution of insula in Parkinson's disease: A quantitative meta-analysis study

Human Brain Mapping
Marion CriaudAntonio P Strafella

Abstract

The insula region is known to be an integrating hub interacting with multiple brain networks involved in cognitive, affective, sensory, and autonomic processes. There is growing evidence suggesting that this region may have an important role in Parkinson's disease (PD). Thus, to investigate the functional organization of the insular cortex and its potential role in parkinsonian features, we used a coordinate-based quantitative meta-analysis approach, the activation likelihood estimation. A total of 132 insular foci were selected from 96 published experiments comprising the five functional categories: cognition, affective/behavioral symptoms, bodily awareness/autonomic function, sensorimotor function, and nonspecific resting functional changes associated with the disease. We found a significant convergence of activation maxima related to PD in different insular regions including anterior and posterior regions bilaterally. This study provides evidence of an important functional distribution of different domains within the insular cortex in PD, particularly in relation to nonmotor aspects, with an influence of medication effect.

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Citations

Aug 30, 2016·Human Brain Mapping·Sang Soo ChoAntonio P Strafella
Sep 13, 2017·European Neurology·Ling-Yan MaTao Feng
Apr 17, 2020·Acta Neurologica Scandinavica·Aline Souza PagnussatAna Francisca Rozin Kleiner
Jul 5, 2018·Brain Imaging and Behavior·Alexander S MihaescuAntonio P Strafella
Mar 27, 2020·Frontiers in Psychiatry·Peiyu HuangMinming Zhang
Sep 28, 2020·Brain : a Journal of Neurology·Christina TremblayAlain Dagher
Jul 21, 2017·NPJ Parkinson's Disease·Roberta BiundoAngelo Antonini
Nov 29, 2016·Frontiers in Aging Neuroscience·Yuko KoshimoriAntonio P Strafella
Dec 13, 2019·Frontiers in Neuroanatomy·Christine IbrahimLeon French
Oct 19, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Luigi Trojano, Costanza Papagno
Jan 8, 2021·Brain Research·Marion CriaudAntonio P Strafella
Dec 26, 2018·NeuroImage. Clinical·Charlotte SpayBénédicte Ballanger
Jan 31, 2020·Neuroscience and Biobehavioral Reviews·Paul FrewenGeorg Northoff
Jul 30, 2021·Ageing Research Reviews·Xiuli DanVilhelm A Bohr

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