Contribution of lead from calcium supplements to blood lead

Environmental Health Perspectives
B L GulsonA J Taylor

Abstract

We conducted a case-control study to determine the contribution of lead to blood from consumption of calcium supplements approximating the recommended daily intakes over a 6-month period. Subjects were males and females ages 21 to 47 years (geometric mean 32 years) with a geometric mean blood lead concentration of 2.5 microg/dL. They were subdivided into three groups. One treatment group (n = 8) was administered a complex calcium supplement (carbonate/phosphate/citrate) and the other treatment group (n = 7) calcium carbonate. The control group (n = 6) received no supplement. The lead isotopic compositions of the supplements were completely different from those of the blood of the subjects, allowing us easily to estimate contribution from the supplements. The daily lead dose from the supplements at 100% compliance was about 3 microg Pb. Three blood samples were taken at 2-month intervals before treatment to provide background values, and three were taken during treatment. Subjects in the treatment group were thus their own controls. Lead isotopic compositions for the complex supplement showed minimal change during treatment compared with pretreatment. Lead isotopic compositions in blood for the calcium carbonate supplement showe...Continue Reading

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Citations

Oct 4, 2002·Environmental Health Perspectives·Brian GulsonKay Waite
Nov 9, 2004·Environmental Health Perspectives·Brian L GulsonKathryn R Mahaffey
Feb 2, 2006·Food Additives and Contaminants·J C P MattosT Emanuelli
Apr 28, 2010·Biological Trace Element Research·Masayuki IkedaJiro Moriguchi
Oct 16, 2012·Analytical and Bioanalytical Chemistry·Ilia RodushkinDouglas C Baxter
Oct 31, 2009·Carcinogenesis·Christopher P Wild, Yun Yun Gong
Nov 27, 2008·Mutagenesis·Christopher P Wild
Aug 16, 2014·Environment International·Suzhen CaoGuibin Jiang
Aug 23, 2008·The Science of the Total Environment·Brian Gulson

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