Contribution of left ventricular residual stress by myocytes and collagen: existence of inter-constituent mechanical interaction

Biomechanics and Modeling in Mechanobiology
Marissa R GrobbelSara Roccabianca

Abstract

We quantify the contribution of myocytes, collagen fibers and their interactions to the residual stress field found in the left ventricle (LV) using both experimental and theoretical methods. Ring tissue samples extracted from normal rat, male and female, LV were treated with collagenase and decellularization to isolate myocytes and collagen fibers, respectively. Opening angle tests were then performed on these samples as well as intact tissue samples containing both constituents that served as control. Our results show that the collagen fibers are the main contributor to the residual stress fields found in the LV. Specifically, opening angle measured in collagen-only samples (106.45[Formula: see text] ± 23.02[Formula: see text]) and myocytes-only samples (21.00[Formula: see text] ± 4.37[Formula: see text]) was significantly higher and lower than that of the control (57.88[Formula: see text] ± 12.29[Formula: see text]), respectively. A constrained mixture (CM) modeling framework was then used to infer these experimental results. We show that the framework cannot reproduce the opening angle found in the intact tissue with measurements made on the collagen-only and myocytes-only samples. Given that the CM framework assumes that e...Continue Reading

References

Jan 1, 1990·Circulation Research·J H Omens, Y C Fung
Jun 1, 1989·Journal of the American College of Cardiology·K T Weber
May 1, 1986·Journal of Biomechanical Engineering·C J Chuong, Y C Fung
Aug 1, 1988·Journal of Biomechanical Engineering·A HorowitzR K Strumpf
Jan 1, 1983·Cardiovascular Research·I Medugorac, R Jacob
Feb 1, 1984·Journal of Biomechanical Engineering·A J Brady
Jul 1, 1994·The American Journal of Physiology·R J HajjarJ K Gwathmey
Mar 1, 1994·The American Journal of Physiology·D A MacKennaJ W Covell
Feb 1, 1993·Circulation Research·L A TaberB B Keller
Mar 1, 1996·Basic Research in Cardiology·D A MacKennaJ W Covell
Sep 1, 1996·Journal of Molecular and Cellular Cardiology·J H OmensA D McCulloch
Jul 21, 1999·Journal of Biomechanical Engineering·J H OmensA D McCulloch
Oct 31, 2003·Biomechanics and Modeling in Mechanobiology·J H OmensJ C Criscione
Dec 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Devinder RehalGhassan S Kassab
Jul 22, 2008·Biophysical Journal·Zhilei L ShenSteven J Eppell
Dec 3, 2008·Journal of Biomechanical Engineering·W ZhangG S Kassab
Mar 6, 2010·Annals of the New York Academy of Sciences·Stephanie L K BowersTroy A Baudino
Jun 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Megan L McCainKevin Kit Parker
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Nov 8, 2013·Annals of Biomedical Engineering·C BelliniJ D Humphrey
Jun 20, 2014·International Journal of Advances in Engineering Sciences and Applied Mathematics·M R BersiJ D Humphrey
Apr 29, 2015·Journal of Biomechanics·M GenetE Kuhl
Oct 4, 2016·Biomechanics and Modeling in Mechanobiology·Reza AvazmohammadiMichael S Sacks

❮ Previous
Next ❯

Citations

Jun 20, 2020·Cardiovascular Engineering and Technology·Xin Zhuan, Xiaoyu Luo
Oct 5, 2020·Biomechanics and Modeling in Mechanobiology·I I Tagiltsev, A V Shutov
Oct 3, 2020·American Journal of Physiology. Heart and Circulatory Physiology·G Andres ContrerasStephanie W Watts
Apr 14, 2019·Acta Biomaterialia·Ce XiLik Chuan Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.