Contribution of lung fibroblast migration in the fibrotic process of airway remodeling in asthma

Allergology International : Official Journal of the Japanese Society of Allergology
Eri YamauchiSankei Nishima

Abstract

The fibrotic process in airway remodeling of asthma may be characterized by an exaggerated deposition of extracellular matrix (ECM) components such as fibronectin and type I, III and IV collagen. In the present study, we established airway remodeling model mice and examined the mechanism of fibrotic change by measuring chemotactic activity of lung fibroblasts and quantifying collagen content in lung tissues. Airway remodeling model mice were made by ovalbumin (OA) sensitization and inhalation. Bronchoalveolar lavage (BAL) and bronchial biopsy were performed. Cell migration was assessed by the Boyden's chamber technique. The collagen content of lung tissue was measured using ELISA. The chemotactic activity in lung fibroblasts toward the mouse BAL fluid (BALF) was significantly increased in OA-inhaled mice. Total soluble collagen content was significantly increased in OA-inhaled mice. We observed markedly increased collagen deposition around the airway wall in OA-inhaled mice, which was not shown in saline-inhaled mice. Furthermore, fibronectin in the BALF of OA-inhaled mice was significantly higher than that in the control mice. The total soluble collagen content increased during the fibrotic change of airway remodeling in asthm...Continue Reading

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Citations

Mar 13, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Stella M HonoréSara S Sánchez
Feb 28, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jon M Evasovic, Cherie A Singer
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vaclav VetvickaJosef Richter
Jun 21, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Ai JinShemin Lu

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