Contribution of lymphoscintigraphy to intraoperative sentinel lymph node detection in early cervical cancer: Analysis of the prospective multicenter SENTICOL cohort

Gynecologic Oncology
Anne-Sophie BatsFabrice Lécuru

Abstract

To evaluate the contribution of preoperative lymphoscintigraphy to intraoperative lymphatic mapping (ILM) in early cervical cancer We conducted an ancillary analysis of the multicenter prospective SENTICOL study in early cervical cancer. Radiocolloid was injected intracervically on the day before (long protocol) or morning of (short protocol) surgery, lymphoscintigraphy was performed, and the results of a centralized image review were communicated to the surgeons. ILM was performed on combined radioactivity/patent blue detection. Sentinel lymph nodes (SLNs) were electively sampled before routine bilateral pelvic lymphadenectomy by laparoscopy. Of 139 patients in the modified intention-to-diagnose analysis, 114 had centrally reviewed lymphoscintigrams, which showed 352 SLNs in 100 patients. Lymphoscintigraphy and ILM detection rates were 87.8% and 97.8%, respectively. Agreement between lymphoscintigraphy and ILM was low for the number of SLNs (κ=0.23; -0.04; 0.49) and bilateral SLNs (κ=0.36; 0.2; 0.52). No patient without SLNs by ILM had SLNs by lymphoscintigraphy. Lymphoscintigraphy identified substantial proportions of unusual drainage pathways. No patients with metastatic nodes had SLNs by lymphoscintigraphy but not by ILM in...Continue Reading

References

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May 30, 2008·Annals of Surgical Oncology·Anne-Sophie BatsEmile Daraï
May 9, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sabas C VieiraLuiz C Zeferino
Mar 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabrice LécuruDaniel Dargent
Sep 7, 2011·Gynecologic Oncology·Anne-Sophie BatsUNKNOWN SENTICOL collaborative group

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Citations

Sep 10, 2015·Journal of Surgical Oncology·Blair Smith, Floor Backes
Apr 5, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Samine SahbaiHelmut Dittmann
Aug 14, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rekha WuntakalOmer Devaja
Sep 20, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Agnieszka RychlikIgnacio Zapardiel
Feb 26, 2016·Clinical Nuclear Medicine·Marco MaccauroDomenico Rubello
Apr 23, 2019·Archives of Gynecology and Obstetrics·G F VercellinoJalid Sehouli
Dec 12, 2020·Minerva ginecologica·Silvia PelligraFrancesco Fanfani
Aug 29, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P AnnedeC Chargari
Dec 10, 2020·Geburtshilfe und Frauenheilkunde·Julia WaldschmidtIngolf Juhasz-Böss
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anne-Sophie NavarroAlejandra Martinez

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