PMID: 9416805Jan 7, 1998Paper

Contribution of mathematical modelling to the interpretation of bedside tests of cerebrovascular autoregulation

Journal of Neurology, Neurosurgery, and Psychiatry
M CzosnykaJ D Pickard

Abstract

Cerebral haemodynamic responses to short and longlasting episodes of decreased cerebral perfusion pressure contain information about the state of autoregulation of cerebral blood flow. Mathematical simulation may help to elucidate which of the indices, that can be derived using transcranial Doppler ultrasonography and trends of intracranial pressure and blood pressure, are useful in clinical tests of autoregulatory reserve. Time dependent interactions between pressure, flow, and volume of cerebral blood and CSF were modelled using a set of non-linear differential equations. The model simulates changes in arterial blood inflow and storage, arteriolar and capillary blood flow controlled by cerebral autoregulation, venous blood storage and venous outflow modulated by changes in ICP, and CSF storage and reabsorption. The model was used to simulate patterns of blood flow during either short or longlasting decreases in cerebral perfusion pressure. These simulations can be considered as clinically equivalent to a short compression of the common carotid artery, systemic hypotension, and intracranial hypertension. Simulations were performed in autoregulating and non-autoregulating systems and compared with recordings obtained in patient...Continue Reading

References

Jan 1, 1978·Acta Anaesthesiologica Scandinavica·G E Cold, F T Jensen
Apr 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·J Ekstedt
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·R AaslidH Nornes
Aug 1, 1987·Journal of Neurosurgery·L M AuerR Pucher
Feb 1, 1984·Journal of Neurosurgery·M J Rosner, D P Becker
May 1, 1982·Journal of Neurosurgery·H D PortnoyM B Shannon
Oct 1, 1995·Stroke; a Journal of Cerebral Circulation·R R DiehlP Berlit
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·P J KirkpatrickJ D Pickard
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J D Pickard, M Czosnyka
Jan 1, 1996·Acta neurochirurgica·M CzosnykaJ D Pickard
Jul 1, 1965·Neurology·T W LANGFITTN F KASSELL

❮ Previous
Next ❯

Citations

Oct 1, 2005·Journal of Mathematical Biology·Andreas JungAlexander Brawanski
May 19, 2006·Annals of Biomedical Engineering·S J Payne, L Tarassenko
Jun 19, 2013·Annals of Biomedical Engineering·V Z MarmarelisR Zhang
Feb 9, 2012·Neurocritical Care·Alfredo Conti, Francesco Tomasello
Aug 6, 2003·Medical Engineering & Physics·Michael L DaleyCharles W Leffler
Apr 4, 2007·Journal of Neurotrauma·Michael L DaleyCharles W Leffler
Sep 8, 2011·Journal of Neurotrauma·Dong-Joo KimMarek Czosnyka
Jun 27, 2012·Brain : a Journal of Neurology·Cheng-Wei LuPeter Smielewski
Sep 9, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B SchmidtJ Klingelhöfer
Feb 25, 2009·Critical Care Medicine·Wayne WakelandBrahm Goldstein
Mar 17, 2010·BMC Anesthesiology·Judith BellapartJohn F Fraser
Feb 24, 2011·BMC Anesthesiology·Judith BellapartJohn F Fraser
Sep 28, 2007·Anesthesia and Analgesia·Iain K Moppett, Jonathan G Hardman
Feb 14, 2002·Neurosurgery·Zofia H CzosnykaJohn D Pickard
Apr 22, 2010·Experimental Biology and Medicine·Michael L DaleyCharles W Leffler
Jun 23, 2012·The Open Biomedical Engineering Journal·Vz MarmarelisR Zhang
Apr 8, 1999·Journal of Neurosurgery·M CzosnykaM Chir
Oct 5, 2013·Neurocritical Care·Georgios V VarsosMarek Czosnyka
Apr 5, 2014·Medical Engineering & Physics·V Z MarmarelisR Zhang
Feb 9, 2012·Neurocritical Care·Nicolás de RivaMarek Czosnyka
Oct 11, 2012·Current Cardiovascular Risk Reports·Vera Novak
Mar 31, 2009·Ultrasound in Medicine & Biology·Judith Bellapart, John F Fraser
Nov 15, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Georgios V VarsosMarek Czosnyka
Nov 5, 2008·Medical Engineering & Physics·T David, S Moore
Sep 2, 2008·Computers in Biology and Medicine·Wayne Wakeland, Brahm Goldstein
Nov 5, 2013·IEEE Transactions on Bio-medical Engineering·Vasilis Z Marmarelis Rong Zhang
Apr 5, 2007·IEEE Transactions on Bio-medical Engineering·Xiao HuNeil Martin
Feb 14, 2008·IEEE Transactions on Bio-medical Engineering·Scott A StevensPaul L Penar
Apr 22, 2011·IEEE Transactions on Bio-medical Engineering·Sima ShahsavariBertil Rydenhag
Jun 8, 2007·Neurological Research·Scott A StevensBruce I Tranmer
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·V Z MarmarelisR Zhang
May 16, 2006·British Journal of Neurosurgery·E C WangI Ng
Jan 1, 2015·Annals of Biomedical Engineering·Greg MaderAdam Mahdi
Jun 9, 2012·Ultrasound in Medicine & Biology·Magdalena KasprowiczMarek Czosnyka
Aug 1, 2014·Frontiers in Neurology·Christopher Hawthorne, Ian Piper
May 6, 2016·Critical Care : the Official Journal of the Critical Care Forum·Joseph DonnellyMarek Czosnyka
Aug 30, 2016·PloS One·Adi TsalachMoshe Kamar
Feb 15, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S K PiechnikJ D Pickard
Nov 13, 2004·Physiological Measurement·Marek CzosnykaJohn D Pickard
May 25, 2012·Critical Care Medicine·Marcel J H AriesPeter Smielewski

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.