Contribution of mechanosensitive ion channels to somatosensation

Progress in Molecular Biology and Translational Science
Reza Sharif-Naeini

Abstract

Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal, is a central mechanism to several physiological functions in mammals. It relies on the function of mechanosensitive ion channels (MSCs). Although the first single-channel recording from MSCs dates back to 30 years ago, the identity of the genes encoding MSCs has remained largely elusive. Because these channels have an important role in the development of mechanical hypersensitivity, a better understanding of their function may lead to the identification of selective inhibitors and generate novel therapeutic pathways in the treatment of chronic pain. Here, I will describe our current understanding of the role MSCs may play in somatosensation and the potential candidate genes proposed to encode them.

Citations

Nov 23, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Paula Alonso-GonzálezJosé A Vega
Sep 15, 2017·Journal of Anatomy·Y García-MesaO García-Suárez
Feb 2, 2019·Current Drug Targets·Amna KhanYeong Shik Kim
Nov 5, 2016·Science·Cedric Peirs, Rebecca P Seal
May 11, 2019·International Journal of Molecular Sciences·Kihwan LeeGehoon Chung
Apr 7, 2020·Journal of Neural Transmission·Reza Sharif-Naeini
Dec 14, 2017·Scientific Reports·Steven Li FraineReza Sharif-Naeini
Apr 8, 2016·Physiology·Eve R SchneiderSlav N Bagriantsev
Sep 2, 2020·International Journal of Molecular Sciences·Ramón CoboJose A Vega

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