Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles?

Diabetes & Metabolism
Jennifer Rieusset

Abstract

Mitochondria and the endoplasmic reticulum (ER) regulate numerous cellular processes, and are critical contributors to cellular and whole-body homoeostasis. More important, mitochondrial dysfunction and ER stress are both closely associated with hepatic and skeletal muscle insulin resistance, thereby playing crucial roles in altered glucose homoeostasis in type 2 diabetes mellitus (T2DM). The accumulated evidence also suggests a potential interrelationship between alterations in both types of organelles, as mitochondrial dysfunction could participate in activation of the unfolded protein response, whereas ER stress could influence mitochondrial function. The fact that mitochondria and the ER are physically and functionally interconnected via mitochondria-associated membranes (MAMs) supports their interrelated roles in the pathophysiology of T2DM. However, the mechanisms that coordinate the interplay between mitochondrial dysfunction and ER stress, and its relevance to the control of glucose homoeostasis, are still unknown. This review evaluates the involvement of mitochondria and ER independently in the development of peripheral insulin resistance, as well as their potential roles in the disruption of organelle crosstalk at MAM...Continue Reading

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Citations

May 12, 2015·Mechanisms of Ageing and Development·Laura CaraviaAna-Maria Enciu
Jun 26, 2017·Biochemical and Biophysical Research Communications·Jennifer Rieusset
Mar 21, 2017·Scientific Reports·Benjamin L FarahPaul M Yen
Aug 5, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Jing LuJin-Kui Yang
Dec 15, 2016·Journal of Molecular Endocrinology·Emily Tubbs, Jennifer Rieusset
May 26, 2018·Nutrients·Sergio Claudio SaccàCarlo Enrico Traverso
Mar 20, 2019·Reviews in Endocrine & Metabolic Disorders·Andrea G Izquierdo, Ana B Crujeiras
Nov 26, 2020·Scientific Reports·Abdoulaye DianeMohammed Dehbi
Nov 5, 2020·International Journal of Molecular Sciences·Flavia GiamoganteTito Calì
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Shanshan YangZhiguang Su
Dec 20, 2020·International Journal of Molecular Sciences·Yi Sun, Shuzhe Ding
Mar 23, 2021·FEBS Letters·Chaonan JinJean-François Dufour
Apr 6, 2021·Frontiers in Endocrinology·Kamila Roszczyc-Owsiejczuk, Piotr Zabielski

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