Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significance"

Cancer Cytopathology
N Paul OhoriYuri E Nikiforov

Abstract

"Follicular lesion of undetermined significance/atypia of undetermined significance" is a heterogeneous category of cases that cannot be classified into 1 of the other established categories. The use of ancillary molecular studies has not been widely explored for this diagnosis. All thyroid cytology cases diagnosed as follicular lesion of undetermined significance/atypia of undetermined significance were retrieved from April 2007 to December 2008. During this time period, samples were collected routinely at the time of aspiration for cytologic and molecular studies. Analysis for BRAF and RAS gene mutations and RET/PTC and PAX8/PPARgamma gene rearrangements were performed and correlated with the cytologic features and surgical pathology outcome. From a total of 513 follicular lesion of undetermined significance/atypia of undetermined significance cases identified, 455 had adequate molecular results. Of these, 117 cases had cytologic-histologic correlation. In this group, 35 (29.9%) cases had a neoplastic outcome and 20 (17.1%) cases from 19 patients were carcinoma. Positive molecular results were found in 12 cases, all of which were papillary carcinoma. There were no false-positive molecular results. In correlating the molecular...Continue Reading

References

May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Marina N NikiforovaYuri E Nikiforov
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Giuliana SalvatoreMassimo Santoro
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Jun 24, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yuri E Nikiforov
Mar 26, 2009·The Journal of Clinical Endocrinology and Metabolism·Yuri E NikiforovMarina N Nikiforova

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Citations

Jun 14, 2012·Der Pathologe·S TingK W Schmid
May 7, 2013·Endocrine·Tada Kunavisarut
Nov 9, 2010·Endocrine Pathology·Elaine Cristina MorariLaura Sterian Ward
Jul 9, 2011·Endocrine Pathology·Feriyl Bhaijee, Yuri E Nikiforov
Oct 15, 2011·Endocrine Pathology·William C FaquinPeter M Sadow
Apr 30, 2013·Endocrine Pathology·Ji Young ParkKyoung Sik Park
Apr 6, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yuri E Nikiforov
May 12, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nidhi AggarwalYuri E Nikiforov
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Mingzhao Xing
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Mar 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Linwah YipSally E Carty
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