Contribution of molecular typing methods and antifungal susceptibility testing to the study of a candidemia cluster in a burn care unit.

Journal of Clinical Microbiology
E Bart-DelabesseF Dromer

Abstract

We investigated a cluster of cases of Candida septicemia diagnosed in four burn patients. Twenty clinical isolates of Candida albicans and two of Candida parapsilosis, plus eight isolates of C. albicans recovered from nurses' clothes, were analyzed by antifungal susceptibility testing and three genotyping methods (restriction fragment length polymorphism analysis with EcoRI and HinfI, arbitrarily primed PCR, and karyotyping). The high MICs of the azoles for all of the C. albicans isolates tested suggest either a natural resistance of the endogenous flora or the transmission of isolates with acquired resistance. The genotyping methods demonstrated the involvement of four different strains, cross-infections with one C. albicans strain and one C. parapsilosis strain, and identity between some of the strains from the patients and nurses. The origins of the strains remain unclear. Our results show that the use of a combination of at least two different methods such as those used in the present study is recommended for C. albicans typing.

References

Mar 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F MeunierN Bitar
Feb 1, 1992·Infection and Immunity·K J Kwon-ChungB L Wickes
Jun 1, 1995·Journal of Clinical Microbiology·A van BelkumH Koeleman
Jan 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A GoffR J Fass
Sep 1, 1994·Journal of Clinical Microbiology·L J StrausbaughR Tjoelker
Nov 1, 1993·Journal of Clinical Microbiology·E Bart-DelabesseB Dupont
Aug 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A Pfaller
Apr 1, 1994·Journal of Clinical Microbiology·A VossB N Doebbeling
Aug 1, 1994·The Journal of Infectious Diseases·E J AnaissieV Paetznick
Apr 1, 1994·Epidemiology and Infection·F RomanoM Giuliano
Oct 1, 1993·Clinical Microbiology Reviews·J H RexJ N Galgiani
Jul 1, 1993·The Journal of Infectious Diseases·J A VazquezM J Zervos

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Citations

Mar 10, 2001·Scandinavian Journal of Infectious Diseases·E PoikonenP Ruutu
Jan 5, 2005·Mycopathologia·Nivedita GuptaRajendra Prasad
May 28, 2002·Canadian Journal of Microbiology·Kathleen M RiedererRiad Khatib
Jul 15, 2004·Memórias do Instituto Oswaldo Cruz·Patrícia M PintoMiriam Tendler
May 9, 1998·Oral Microbiology and Immunology·J HannulaS Asikainen
Mar 31, 2004·Memórias do Instituto Oswaldo Cruz·Meltem Yalinay CirakSemra Kustimur
Jul 16, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lucia Garcia San MiguelSantiago Moreno
May 11, 2001·Medical Mycology·A M Le MonteUNKNOWN National Institute of Allergy and Infectious Disease Mycoses Study Group
Jun 20, 1998·Clinical Microbiology Reviews·T C WhiteR A Bowden
Apr 2, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Gil-LamaignereF-M C Müller
Feb 7, 2001·Clinical Microbiology Reviews·D R Soll

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