PMID: 8091330Aug 1, 1994Paper

Contribution of multiple inert gas elimination technique to pulmonary medicine. 1. Principles and information content of the multiple inert gas elimination technique

Thorax
J Roca, P D Wagner

Abstract

This introductory review summarises four different aspects of the multiple inert gas elimination technique (MIGET). Firstly, the historical background that facilitated, in the mid 1970s, the development of the MIGET as a tool to obtain more information about the entire spectrum of VA/Q distribution in the lung by measuring the exchange of six gases of different solubility in trace concentrations. Its principle is based on the observation that the retention (or excretion) of any gas is dependent on the solubility (lambda) of that gas and the VA/Q distribution. A second major aspect is the analysis of the information content and limitations of the technique. During the last 15 years a substantial amount of clinical research using the MIGET has been generated by several groups around the world. The technique has been shown to be adequate in understanding the mechanisms of hypoxaemia in different forms of pulmonary disease and the effects of therapeutic interventions, but also in separately determining the quantitative role of each extrapulmonary factor on systemic arterial PO2 when they change between two conditions of MIGET measurement. This information will be extensively reviewed in the forthcoming articles of this series. Next...Continue Reading

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Citations

Mar 26, 2010·Annals of Biomedical Engineering·Joseph C Anderson, Michael P Hlastala
Jul 4, 2001·Journal of Hepatology·G P MartínezR Rodriguez-Roisin
Jun 12, 1999·Journal of Hepatology·G MartinezR Rodriguez-Roisin
Jan 11, 2001·Acta Anaesthesiologica Scandinavica·P Neumann, G Hedenstierna
Aug 24, 2006·British Journal of Anaesthesia·J S YemA B H Crawford
Sep 28, 2002·Critical Care Medicine·Alex LoeckingerKarl H Lindner
Aug 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·H L Smith, J G Jones
Aug 1, 1997·Thorax·A T Jones, T W Evans
Jun 2, 2012·Journal of Applied Physiology·Brett A SimonGrace Parraga
Jan 15, 2011·Journal of Applied Physiology·George CremonaPeter D Wagner
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·O DíazR Rodriguez-Roisin
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J CardúsP D Wagner
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·N RogerR Rodriguez-Roisin
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·A G AgustíR Rodriguez-Roisin
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·F P GómezR Rodriguez-Roisin
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·C SantosR Rodriguez-Roisin
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·A KleinsasserK H Lindner
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·A L EchazarretaR Rodriguez-Roisin
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·M ManciniR Rodriguez-Roisin
Mar 17, 2007·American Journal of Respiratory and Critical Care Medicine·Benjamin HarrisGregory G King
Apr 14, 2007·American Journal of Respiratory and Critical Care Medicine·Eva PolverinoRoberto Rodríguez-Roisin
Oct 31, 2009·American Journal of Respiratory and Critical Care Medicine·Isabel BlancoJoan Albert Barberà
Nov 5, 2008·Critical Care : the Official Journal of the Critical Care Forum·Dirk VarelmannHermann Wrigge
May 29, 2002·Anesthesia and Analgesia·Rolf DembinskiRalf Kuhlen
Jan 16, 2007·The Journal of Physiology·Amy M JonkPeter D Wagner
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Federico P GómezRobert Rodríguez-Roisin
Apr 19, 2011·Archivos de bronconeumología·Diego A RodríguezRoberto Rodríguez-Roisin
Jan 20, 2010·Journal of Theoretical Biology·Angela ReynoldsGilles Clermont
May 24, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wolfram MiekischJochen K Schubert
Mar 5, 2015·Journal of Critical Care·Ana TejedorJaume Balust
Mar 30, 2013·Respiratory Physiology & Neurobiology·Federico P GómezJoan A Barberà

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