Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical murine saccular aneurysm model

Neurosurgery
Juhana FrösenJuha E Jääskeläinen

Abstract

Endovascular occlusive therapy of human saccular cerebral artery aneurysms may fail because of thrombus recanalization and incomplete neointima formation. Bone marrow-derived progenitor cells may contribute to these processes, but their role in human saccular cerebral artery aneurysms and experimental aneurysm models remains unclear. Experimental saccular aneurysms were constructed from syngeneic thoracic aortas transplanted end-to-side to the abdominal aorta of Wistar rats (n = 14), C57/B6 mice (n = 13), ApoE mice (n = 7), reporter gene expressing ROSA mice (n = 7), and mice with labeled bone marrow (ROSA [n = 12] or green fluorescent protein [n = 3]). Magnetic resonance imaging or angiography was used to monitor patency of the experimental aneurysms. Histology and immunohistochemistry were used to study thrombus organization and neointima formation and X-gal staining and confocal microscopy to study the origin of neointimal cells. Experimental aneurysms developed luminal pads of neointimal hyperplasia or organizing thrombosis that became thicker and occluded partly the lumen at later time points during the first week. Reporter gene mice (ROSA) revealed that 42 to 81% (median, 58%) of neointimal hyperplasia/organizing thrombos...Continue Reading

References

Oct 1, 1994·Neuroradiology·G GuglielmiJ Robert
Jul 1, 1994·Journal of Neuropathology and Experimental Neurology·T A KosierkiewiczD W Dickson
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·J W HopJ van Gijn
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·S KondoH Kataoka
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Masafumi MorimotoNobuo Hashimoto
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan-Luuk HillebrandsJan Rozing
May 31, 2003·Stroke; a Journal of Cerebral Circulation·Jean RaymondDaniel Roy
Jul 19, 2003·Stroke; a Journal of Cerebral Circulation·Yuichi MurayamaFernando Vinuela
Nov 8, 2003·Stroke; a Journal of Cerebral Circulation·Jean RaymondAlain Weill
Feb 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Gerard PasterkampDominique P V de Kleijn
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·Edith Ribourtout, Jean Raymond
Apr 24, 2004·Stroke; a Journal of Cerebral Circulation·Jean RaymondOlivier Robledo
Aug 18, 2004·Circulation·Arjun DebNoel M Caplice

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Citations

Jan 18, 2012·Acta Neuropathologica·Juhana FrösenJuha Hernesniemi
Dec 15, 2010·Neurosurgery·Rossana RomaniJuha Hernesniemi
Dec 11, 2013·Translational Stroke Research·Robert M StarkeAaron S Dumont
Oct 3, 2013·Radiology·Ramanathan KadirvelDavid F Kallmes
Oct 31, 2009·AJNR. American Journal of Neuroradiology·F BouzeghraneUNKNOWN International Consortium of Neuroendovascular Centres
Nov 26, 2015·Journal of Biomechanics·Jiayao MaRafik R Rizkallah
May 22, 2007·Surgical Neurology·Reza DashtiJuha E Jääskeläinen
Jul 22, 2014·Brain Pathology·Yutang WangJonathan Golledge
Jul 3, 2018·European Journal of Clinical Investigation·Mannekomba R DiagbougaBrenda R Kwak
Jan 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean SénémaudRaphaël Coscas
Nov 14, 2013·Stroke; a Journal of Cerebral Circulation·Serge MarbacherJuhana Frösen
Nov 6, 2014·Stroke; a Journal of Cerebral Circulation·Serge MarbacherMika Niemelä
Jul 2, 2019·Neurosurgical Focus·John W ThompsonRobert M Starke
Mar 11, 2019·Journal of Neurointerventional Surgery·Basil Erwin GrüterDaniel Coluccia
Jul 25, 2018·Journal of Neurointerventional Surgery·Riikka TulamoMika Niemelä
Dec 25, 2019·Journal of Neurointerventional Surgery·Edin NevzatiSerge Marbacher
May 23, 2013·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·K NambaS Nemoto
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Serge MarbacherJavier Fandino
Sep 14, 2017·Translational Stroke Research·Daniel L CookeZhengda Sun
Feb 20, 2020·Brain Sciences·Serge MarbacherJavier Fandino
Nov 8, 2020·Journal of Neurointerventional Surgery·Wenjing LiuRamanathan Kadirvel
Jan 29, 2021·Stroke; a Journal of Cerebral Circulation·Basil E GrüterSerge Marbacher
Nov 15, 2020·Journal of Neurointerventional Surgery·Basil Erwin Grüter, Serge Marbacher

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