Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training

Circulation
Massimo F PiepoliA J Coats

Abstract

A neural linkage between peripheral abnormalities and the exaggerated exercise responses in chronic heart failure (CHF) was postulated. We studied the ergoreceptors (afferents sensitive to skeletal muscle work) in CHF and whether training can affect their activity. In 12 stable CHF patients (ejection fraction [EF] = 26.4%) and 10 control subjects (EF = 55.3%), we compared the responses to dynamic handgrip and during a 3-minute period of posthandgrip regional circulatory occlusion (PH-RCO). The ergoreflex contribution was quantified as the percentage responses to exercise maintained by PH-RCO compared with recovery without PH-RCO. Patients showed ergoreflex overactivation compared with control subjects in terms of ventilation (86.5% versus 54.5%), diastolic pressure (97.8% versus 53.5%), and leg vascular resistance (108.1% versus 48.9%) (all P < .05). The contribution of the ergoreflex to vagal withdrawal (high frequency of RR variability) and sympathetic activation (low frequency of RR, pressure variability) was evident in both groups. Nine control subjects and nine CHF patients participated in 6 weeks of forearm training. Training reduced the ergoreflex contributions more in CHF than in control subjects: diastolic pressure (-3...Continue Reading

References

Feb 1, 1979·Respiration Physiology·N J Davies, D M Denison
Jul 1, 1979·British Journal of Clinical Pharmacology·M Hills, P Armitage
Jan 1, 1991·British Heart Journal·N P BullerP A Poole-Wilson
Oct 1, 1990·Acta Anaesthesiologica Scandinavica·D B FriedmanN H Secher
Sep 1, 1990·The Journal of Clinical Investigation·J R MinottiM V Icenogle
Feb 1, 1988·International Journal of Cardiology·D P LipkinP A Poole-Wilson
Feb 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·A M Kulik
Apr 1, 1985·The American Journal of Cardiology·J SzlachcicJ Tubau
Sep 1, 1985·British Heart Journal·D P LipkinP A Poole-Wilson
Sep 1, 1984·Annals of Internal Medicine·G S FrancisJ N Cohn
Oct 1, 1995·The American Journal of Physiology·M PiepoliA J Coats
May 1, 1995·European Journal of Clinical Investigation·A L ClarkA J Coats
Aug 1, 1994·British Heart Journal·A J CoatsP A Poole-Wilson
Apr 1, 1994·Journal of Applied Physiology·J R StrattonB Rajagopalan
Aug 21, 1993·Lancet·D Walsh
Oct 1, 1993·Journal of the American College of Cardiology·M D ThamesM E Dibner-Dunlap
Oct 1, 1993·Journal of the American College of Cardiology·J S Floras
Apr 1, 1993·Journal of the American College of Cardiology·S AdamopoulosG K Radda
May 1, 1963·British Medical Bulletin·A D GREENFIELDJ F MOWBRAY

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Citations

Aug 28, 2007·European Journal of Applied Physiology·Fernanda Patti NakamotoAntônio Carlos Silva
Jan 24, 2007·Current Heart Failure Reports·Massimo F Piepoli
May 11, 2006·Current Heart Failure Reports·Massimo F Piepoli
Apr 29, 2010·Current Heart Failure Reports·Ferdinando IellamoMaurizio Volterrani
Mar 21, 2012·Current Heart Failure Reports·Panagiota Georgiadou, Stamatis Adamopoulos
Jun 26, 2012·Endocrine·Maurizio VolterraniFerdinando Iellamo
Jun 11, 2005·Journal of Cardiac Failure·Andrew L Clark, John G F Cleland
Jul 1, 1997·The American Journal of Cardiology·K MeyerH Roskamm
Jun 17, 2000·Transplantation Proceedings·T Ben-GalD Aravot
Jun 25, 2003·International Journal of Cardiology·Stamatis AdamopoulosDimitrios Th Kremastinos
Apr 18, 1997·International Journal of Cardiology·A ClarkK Arbuthnott
Apr 3, 1999·International Journal of Cardiology·D A GrieveW S Hillis
Nov 13, 2002·Journal of the American College of Cardiology·Ainat BeniaminovitzDonna M Mancini
Sep 6, 2003·Journal of the American College of Cardiology·Fabiana RovedaCarlos Eduardo Negrão
Nov 1, 1996·Journal of the American College of Cardiology·A L ClarkA J Coats
Mar 18, 1999·Journal of the American College of Cardiology·W JohnsonM A Creager
Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G A MacGowanS Murali
Jun 20, 2001·Acta Physiologica Scandinavica·M F PiepoliA J Coats
Jun 20, 2001·Acta Physiologica Scandinavica·G VescovoL Dalla Libera
Apr 12, 2001·European Journal of Clinical Investigation·T GustafssonE Jansson
Apr 14, 2012·International Journal of Sports Medicine·J U GonzalesD N Proctor
Feb 2, 2013·Journal of Palliative Medicine·Stephen G OxberryMiriam J Johnson
Dec 18, 2012·European Heart Journal·Petra BarthelGeorg Schmidt
Sep 29, 1998·Critical Care Medicine·J W Severinghaus
Sep 10, 1998·Journal of Cardiovascular Pharmacology·M MetraL Dei Cas

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