Contribution of mutation, recombination, and gene conversion to chicken MHC-B haplotype diversity.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Kazuyoshi HosomichiTakashi Shiina

Abstract

The Mhc is a highly conserved gene region especially interesting to geneticists because of the rapid evolution of gene families found within it. High levels of Mhc genetic diversity often exist within populations. The chicken Mhc is the focus of considerable interest because of the strong, reproducible infectious disease associations found with particular Mhc-B haplotypes. Sequence data for Mhc-B haplotypes have been lacking thereby hampering efforts to systematically resolve which genes within the Mhc-B region contribute to well-defined Mhc-B-associated disease responses. To better understand the genetic factors that generate and maintain genomic diversity in the Mhc-B region, we determined the complete genomic sequence for 14 Mhc-B haplotypes across a region of 59 kb that encompasses 14 gene loci ranging from BG1 to BF2. We compared the sequences using alignment, phylogenetic, and genome profiling methods. We identified gene structural changes, synonymous and non-synonymous polymorphisms, insertions and deletions, and allelic gene rearrangements or exchanges that contribute to haplotype diversity. Mhc-B haplotype diversity appears to be generated by a number of mutational events. We found evidence that some Mhc-B haplotypes a...Continue Reading

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Citations

May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tim DowningDaniel G Bradley
May 14, 2010·Molecular Biology and Evolution·Reto BurriLuca Fumagalli
Oct 23, 2010·Molecular Biology and Evolution·Rafael D RosengartenStephen L Dellaporta
Jan 11, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Shingo SuzukiKei Hanzawa
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lee D ChavesKent M Reed
Apr 3, 2010·BMC Biology·Christopher N BalakrishnanScott V Edwards
Mar 5, 2010·The Journal of Heredity·Jennifer L BollmerCharles Wimpee
Sep 16, 2016·Open Biology·John ChattawayJim Kaufman
Jul 25, 2018·Immunogenetics·Keith T BallingallSteven G E Marsh
Aug 3, 2012·Molecular Biology and Evolution·Andrea Gloria-SoriaLeo W Buss
Nov 21, 2013·Immunogenetics·Weerachai JaratlerdsiriJaime Gongora
Jul 3, 2017·Immunogenetics·Yuanyuan ChengKatherine Belov
Jun 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ximena Fleming-CanepaKatharine E Magor
Jun 20, 2013·Animal Biotechnology·Miranda M BauerKent M Reed
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ronald M GotoMarcia M Miller
Apr 13, 2021·Molecular Immunology·Clive A Tregaskes, Jim Kaufman
Jul 25, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tereza AlmeidaMartin F Flajnik

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