Contribution of native kidney function to total glomerular filtration rate after combined kidney-pancreas transplantation

Transplantation
M PascualA B Cosimi

Abstract

Combined kidney-pancreas transplantation (CKPT) with its associated euglycemia has been shown to prevent or reduce recurrent diabetic nephropathy in the renal allograft. There has been no evaluation of residual native kidney function after CKPT. The purpose of this study was to determine whether native kidney function may be present in diabetic recipients years after CKPT. Between 1986 and 1992, 37 patients with type 1 insulin-dependent diabetes mellitus with renal failure underwent CKPT. In each case, a single native nephrectomy was performed. We studied 16 patients who had continuing renal and pancreas function more than 4 years after CKPT. Fourteen diabetics with a functioning renal allograft but no pancreas function were used as a control group. Simultaneous renal scans (technetium-99m diethylenetriamine pentaacetic acid) of the native and transplanted kidneys were obtained with a dual-head scintillation camera. Total glomerular filtration rate (GFR) was determined from the rate of clearance of the tracer from the extracellular space measured for 2 hr with an ambulatory renal monitor. The study groups had similar pretransplant characteristics. At the time of the study, the mean serum creatinine level was not significantly d...Continue Reading

References

May 1, 1988·Archives of Surgery·A B CosimiP S Russell
Jan 15, 1995·Transplantation·E GómezJ Alvarez-Grande
Jan 1, 1994·Journal of the American Society of Nephrology : JASN·C A RabitoR Teplick
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Mar 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D PirschM R Weir
Jul 1, 1996·Current Opinion in Nephrology and Hypertension·H S Mackenzie, B M Brenner

❮ Previous
Next ❯

Citations

Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kevin C AbbottLawrence Y Agodoa
Nov 11, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giorgina Barbara PiccoliGiuseppe Paolo Segoloni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.