Contribution of NMR to the assessment of dyslipidemia-related cardiovascular risk

Annales pharmaceutiques françaises
D Bonnefont-RousselotM J Chapman

Abstract

Serum level of cholesterol bound to low density lipoproteins (LDL-cholesterol) is the basic parameter used to assess lipid-related cardiovascular risk. This parameter however underestimates the number of small dense LDLs that are especially atherogenic. A new analytic proposal is based on the determination of lipoproteinic profiles obtained by NMR (Liposcience, Raleigh, NC, United-States [Am J Cardiol 90 (2002) 22i-29i]; collaboration with M.J. Chapman, Inserm U551), that allows to quantify the number of atherogenic apo B-100-containing particles. This analysis is rapid, reproducible and does not require a previous separation of lipoproteins by ultracentrifugation. NMR signals come from the terminal methyl groups of lipids located in the envelope and the core of lipoproteins. Each lipoprotein subclass produces a specific NMR signal, so that analysis of the contribution of each signal to the global signal gives the concentration of particles subclasses (nanomole per litre or micromole per litre), concentration in mass of lipid subclasses (milligram per decilitre of cholesterol or triglycerides), together with mean diameters (nanometre) of very low density lipoproteins (VLDLs), low density lipoproteins (LDLs) and high density lip...Continue Reading

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Citations

Jul 10, 2018·European Heart Journal·Ulrich Laufs, Oliver Weingärtner

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