Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain

Molecular Psychiatry
Jacqueline BorgLars Farde

Abstract

The dopamine (DA) and serotonin (5-HT) neurotransmission systems are of fundamental importance for normal brain function and serve as targets for treatment of major neuropsychiatric disorders. Despite central interest for these neurotransmission systems in psychiatry research, little is known about the regulation of receptor and transporter density levels. This lack of knowledge obscures interpretation of differences in protein availability reported in psychiatric patients. In this study, we used positron emission tomography (PET) in a twin design to estimate the relative contribution of genetic and environmental factors, respectively, on dopaminergic and serotonergic markers in the living human brain. Eleven monozygotic and 10 dizygotic healthy male twin pairs were examined with PET and [(11)C]raclopride binding to the D2- and D3-dopamine receptor and [(11)C]WAY100635 binding to the serotonin 5-HT1A receptor. Heritability, shared environmental effects and individual-specific non-shared effects were estimated for regional D2/3 and 5-HT1A receptor availability in projection areas. We found a major contribution of genetic factors (0.67) on individual variability in striatal D2/3 receptor binding and a major contribution of enviro...Continue Reading

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Citations

Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lars FardeSimon Cervenka
Jun 1, 2016·Synapse·Sarah A EisensteinTamara Hershey
Mar 9, 2019·Molecular Neurobiology·Mikaeel ValliAntonio P Strafella

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