PMID: 19942981Nov 28, 2009Paper

Contribution of nuclear texture analysis for the differential diagnosis of follicular lesions of the thyroid: comparison to immunohistochemical markers

Arquivos brasileiros de endocrinologia e metabologia
Rita C FerreiraPatrícia S de Matos

Abstract

To investigate the utility of nuclear chromatin texture assessment in the differential diagnosis of follicular patterned lesions, by means of examining 76 samples previously submitted to the immunohistochemical protein analysis of HBME-1, CK-19 and galectina-3. HBME-1 confirmed to be the most sensitive marker of malignancy. A series of morphometric, densitometric and texture variables were useful in the discrimination of the different types of follicular lesions. Among these variables, r(2), a parameter related to the granularity of the nucleus presented the best accuracy, sensitivity, specificity and positive and negative predictive values, distinguishing benign from malignant lesions. The morphometric analysis of nuclear chromatin images may add accuracy to the differential diagnosis of follicular patterned lesions.

References

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Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Luciane MartinsEdna T Kimura
Nov 1, 2002·The American Journal of Surgical Pathology·Mitsuyoshi HirokawaKennichi Kakudo
Jul 8, 2003·Microscopy Research and Technique·Shin-Ichi MurataRyohei Katoh
Nov 14, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jonas FeilchenfeldtChristoph A Meier
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·James A FaginEdna T Kimura
Mar 5, 2008·Pediatric Blood & Cancer·Laura Sterian WardLigia Vera Montalli Assumpcao
Sep 13, 2008·World Journal of Surgery·Konradin MetzePatrícia S de Matos

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Citations

Dec 6, 2012·Cellular Oncology (Dordrecht)·R C FerreiraL S Ward
May 23, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anna M BrownJohn Griffiths

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