Contribution of obstructive sleep apnoea to arterial stiffness: a meta-analysis using individual patient data

Thorax
Marie Joyeux-FaureJean-Louis Pépin

Abstract

Arterial stiffness, measured by pulse wave velocity (PWV), is a strong independent predictor of late cardiovascular events and mortality. It is recognised that obstructive sleep apnoea (OSA) is associated with cardiovascular comorbidities and mortality. Although previous meta-analyses concluded that PWV is elevated in OSA, we feel that an individual patient data analysis from nine relatively homogeneous studies could help answer: to what extent does OSA drive arterial stiffness? Individual data from well-characterised patients referred for suspicion of OSA, included in nine studies in which carotid-femoral PWV was measured using a Complior device, were merged for an individual patient data meta-analysis. 893 subjects were included (age: 56±11 (mean±SD), 72% men, 84% with confirmed OSA). Body Mass Index varied from 15 to 81 kg/m2 (30±7 kg/m2). PWV ranged from 5.3 to 20.5 m/s (10.4±2.3 m/s). In univariate analysis, log(PWV) was strongly related to age, gender, systolic blood pressure, presence of type 2 diabetes (all p<0.01) as well as to dyslipidaemia (p=0.03) and an Epworth Sleepiness Scale score ≥9 (p=0.04), whereas it was not related to obesity (p=0.54), a severe Apnoea-Hypopnoea Index (p=0.14), mean nocturnal saturation (p=0...Continue Reading

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Citations

May 14, 2020·Sleep & Breathing = Schlaf & Atmung·Yuhong ChenGang Wu
Aug 18, 2020·Journal of Human Hypertension·Cesare CuspidiGuido Grassi
Oct 24, 2020·Sleep & Breathing = Schlaf & Atmung·Sintya T ChalegreRodrigo P Pedrosa
Apr 3, 2020·Sleep Medicine Reviews·Vanessa BironneauFrédéric Gagnadoux
Jun 3, 2021·International Journal of Molecular Sciences·Jakub MocholAdrian Doroszko
Jun 26, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Yoshinari NakatsukaKazuo Chin

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