Abstract
Despite the advances in pre-, peri- and post-operative medical care of colorectal carcinoma patients, the prognosis has improved only marginally over recent decades. Thus, additional prognostic indicators would be of great clinical value to select patients for adjuvant therapy. In previous studies we found that colorectal carcinomas have a marked increase of the urokinase-type of plasminogen activator (u-PA), and the inhibitors PAI-1 and PAI-2, whereas the tissue-type plasminogen activator (t-PA) is found to be decreased in comparison with adjacent normal mucosa. In the present study we evaluated the prognostic value of several plasminogen activation parameters, determined in both normal and carcinomatous tissue from colorectal resection specimens, for overall survival of 136 Dukes' stage B and C colorectal cancer patients, in relation to major clinicopathological parameters. Uni- and multivariate analyses indicated that a high PAI-2 antigen level in carcinoma, a low t-PA activity and antigen level and a high u-PA/t-PA antigen ratio in adjacent normal mucosa are significantly associated with a poor overall survival. A high ratio of u-PA antigen in the carcinomas and t-PA antigen in normal mucosa, i.e. u-PA(C)/t-PA(N), was found...Continue Reading
Citations
Apr 26, 2005·Annals of Surgery·Todd W BauerLee M Ellis
Nov 18, 2010·Expert Review of Molecular Diagnostics·Manfred SchmittNadia Harbeck
Feb 16, 2012·The Journal of Biological Chemistry·Brett StringerToni M Antalis
May 29, 2000·Journal of Gastroenterology and Hepatology·T ItohH Itoh
Nov 14, 1998·Annals of Medicine·C M FerrierD J Ruiter
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T P HansenO Kronborg
Oct 19, 1999·Thyroid : Official Journal of the American Thyroid Association·J W SmitB M Goslings
Nov 1, 2002·The International Journal of Biological Markers·L SanzJ L García-Muñíz
Oct 23, 2002·The British Journal of Surgery·M BergströmL Holmdahl
Dec 22, 2005·Journal of Cancer Research and Clinical Oncology·Gabriel ScicoloneVladimir Flores
Mar 6, 2003·Journal of Surgical Oncology·Da-Qiang SeetooJia-Lin Yang
Jun 2, 2009·Cancer·George Van BurenLee M Ellis
Oct 14, 2014·World Journal of Gastroenterology : WJG·László HerszényiZsolt Tulassay
Jul 13, 2002·Expert Review of Anticancer Therapy·F GrazianoS Cascinu
Apr 5, 2012·British Journal of Cancer·A M J LangersC F M Sier
Aug 21, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·László HerszényiFabio Farinati
Dec 27, 2011·Journal of Cancer Research and Clinical Oncology·Gianluigi MazzoccoliAda Piepoli
Nov 17, 2001·Diseases of the Colon and Rectum·G BurdyP Valleur
Oct 3, 1999·Cancer·L HerszènyiF Farinati
Jan 15, 1999·British Journal of Cancer·H L McLeod, G I Murray
Jul 12, 2008·BMC Cancer·László HerszényiZsolt Tulassay
Sep 29, 2000·International Journal of Cancer. Journal International Du Cancer·J L YangP J Crowe
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·L HerszényiF Farinati
May 30, 2003·Surgery·David H BergerR Daniel Beauchamp
Aug 27, 1998·Seminars in Oncology Nursing·P J Haylock