Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment

Transactions of the Royal Society of Tropical Medicine and Hygiene
R PremaratnaH Janaka de Silva

Abstract

Twenty-eight febrile Sri Lankan patients with undiagnosed fever for 7 days after hospital admission, who responded to empirical treatment with doxycycline, were retrospectively investigated using microimmunofluorescence assay to verify whether they had rickettsial infection. Eleven (39%) patients were confirmed as having spotted fever group rickettsioses and 10 (36%) as having Orientia tsutsugamushi. Seven were negative for all tests. This suggests that greater use of doxycycline appears justified for patients with undiagnosed fever in settings where rickettsial diseases are endemic or re-emerging with inadequate diagnostic facilities.

References

Sep 3, 2003·Tropical Medicine & International Health : TM & IH·S A M KularatneI Kaiho
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R PremaratnaH J de Silva
Sep 29, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·R PremaratnaH J de Silva

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Citations

Sep 16, 2015·BMC Research Notes·Ranjan PremaratnaH Janaka de Silva
Jul 23, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S A M KularatneR Premaratna

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