Contribution of serum IgA to intestinal lymph IgA, and vice versa, in minipigs

Veterinary Immunology and Immunopathology
J P VaermanH J Rothkötter

Abstract

Immune cells in pig gut lymph are rather well studied, but data on gut lymph immunoglobulins and their origin are nonexistent. Such data are important to understand the interplay between pig systemic and intestinal immunity as a basis for vaccination studies. In some species, gut lymph contributes much to plasma IgA, but apparently not in humans. To estimate the contributions of pig serum IgA to intestinal lymph IgA and vice versa, concentrations of IgA, IgG, IgM, albumin, haptoglobin, C3 and alpha 2-macroglobulin were measured by radial immunodiffusion in paired porcine intestinal lymph and serum samples. All proteins, except IgA, had lymph/serum ratios (< 1.0) inversely related to their size, depending on passive diffusion from serum. The mean lymph/serum ratio of IgA was 2.2 instead of an expected 0.50 or 0.65 (dimer or monomer, respectively), indicating that of the IgA in gut lymph, 22.7 or 29.5% came from serum, vs 77.3 or 70.5% from the intestine. Percentage of polymeric IgA, measured by gelfiltration and corrected radial immunodiffusion, was 64.3% in porcine mesenteric lymph and 47.3% in serum. As the pig plasma volume and daily gut lymph flow into circulation were known, it could be calculated that roughly 31% of the to...Continue Reading

References

Sep 1, 1985·European Journal of Immunology·D L DelacroixJ P Vaerman
Sep 1, 1973·European Journal of Immunology·J P VaermanJ F Heremans
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Feb 1, 1981·Veterinary Immunology and Immunopathology·J E ButlerE Werhahn
Mar 1, 1995·European Journal of Immunology·H J RothkötterR Pabst
Oct 1, 1994·Veterinary Immunology and Immunopathology·J E Butler, W R Brown
Jan 1, 1997·Immunology Letters·J P Vaerman, A Langendries

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Citations

Jan 5, 2014·Developmental and Comparative Immunology·Benoît LevastHenri Salmon
Sep 2, 2008·Developmental and Comparative Immunology·Henri SalmonFrançois Meurens
Sep 9, 2008·Developmental and Comparative Immunology·Hermann-Josef Rothkötter
Aug 20, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jin-Yuarn LinHow-Lan Liou
Jul 19, 2015·Developmental and Comparative Immunology·E R Guzman-BautistaM A Vega-Lopez
Sep 20, 2005·Developmental and Comparative Immunology·John E ButlerMarek Sinkora
Sep 23, 2008·Developmental and Comparative Immunology·J E ButlerI Kacskovics
Apr 14, 2006·Veterinary Research·Veerle SnoeckEric Cox
Jul 2, 2010·Veterinary Immunology and Immunopathology·Benoît LevastFrançois Meurens

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