Contribution of smoking habit to the prognosis of stage I KRAS-mutated non-small cell lung cancer

Cancer Biomarkers : Section a of Disease Markers
Hiroaki KurodaYukinori Sakao

Abstract

One of the known risk factors for non-small cell lung cancer (NSCLC) is somatic mutation in the Kirsten rat sarcoma (KRAS) gene. The relationship with smoking is well known. We retrospectively studied the data of 92 patients who underwent pulmonary resection January 2003 and June 2012 and were diagnosed as KRAS-mutated pathological stage I adenocarcinoma. Among them, 33 patients who were non to light smoker (NLS) (smoking index, 0 to 400) were compared with 59 middle to heavy smoker (MHS) (> 400). The 5-year overall survival (OS) was significantly better in NLS (96.9%) than in MHS (80.0%); however, no significant difference was observed compared with wild-type KRAS (92.8%) (p= 0.66). The presence of p53 was significantly associated with smoking history (p< 0.01). The 5-year OS for NLS with p53-negative KRAS codon 12-mutated NSCLC (n= 28) was significantly better (96.3%) than that for MHS with both p53-positive and -negative KRAS mutation (p= 0.03 and p< 0.03, respectively). A non to light smoking habit might contribute to an improvement in prognosis that is equivalent to that of wild-type KRAS, and p53 mutation did not affect survival in smokers harboring KRAS codon 12.

References

Aug 30, 1990·The New England Journal of Medicine·R J SlebosW J Mooi
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S L GrazianoB J Poiesz
Jan 14, 2004·Chest·C Martin TammemagiPaul Kvale
Apr 20, 2005·Oncogene·Sandra L Harris, Arnold J Levine
May 19, 2005·Seminars in Roentgenology·Mary Beth BeasleyWilliam D Travis
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Issan Yee San TamMaria P Wong
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ming-Sound TsaoFrances A Shepherd
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J RielyMarc Ladanyi
Dec 20, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Takayuki KosakaTetsuya Mitsudomi
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Feb 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yang ZhangHaiquan Chen
Sep 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Snjezana DoganMarc Ladanyi
Dec 25, 2012·Genes & Cancer·Ahmed El-Telbany, Patrick C Ma
Apr 27, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natasha RekhtmanAndre L Moreira
May 1, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frances A ShepherdMing-Sound Tsao
Apr 29, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mihaly CserepesBalazs Dome
May 28, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eun Young KimYoon Soo Chang
Aug 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Benjamin IzarMichael Lanuti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.