Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Frontiers in Neuroscience
María J PérezRodrigo A Quintanilla

Abstract

Tau is an essential protein that physiologically promotes the assembly and stabilization of microtubules, and participates in neuronal development, axonal transport, and neuronal polarity. However, in a number of neurodegenerative diseases, including Alzheimer's disease (AD), tau undergoes pathological modifications in which soluble tau assembles into insoluble filaments, leading to synaptic failure and neurodegeneration. Mitochondria are responsible for energy supply, detoxification, and communication in brain cells, and important evidence suggests that mitochondrial failure could have a pivotal role in the pathogenesis of AD. In this context, our group and others investigated the negative effects of tau pathology on specific neuronal functions. In particular, we observed that the presence of these tau forms could affect mitochondrial function at three different levels: (i) mitochondrial transport, (ii) morphology, and (iii) bioenergetics. Therefore, mitochondrial dysfunction mediated by anomalous tau modifications represents a novel mechanism by which these forms contribute to the pathogenesis of AD. In this review, we will discuss the main results reported on pathological tau modifications and their effects on mitochondrial ...Continue Reading

References

Jul 1, 1979·Archives of Biochemistry and Biophysics·R A Haworth, D R Hunter
Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·A C AlonsoK Iqbal
Aug 10, 1999·Toxicology and Applied Pharmacology·D A Di MonteJ W Langston
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·A AlonsoK Iqbal
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark RapoportAdriana Ferreira
Nov 19, 2002·Neuroscience Letters·Hans FribergRoger F Castilho
Dec 31, 2002·Neurobiology of Disease·Troy T RohnElizabeth Head
Jul 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·T Chris GamblinVincent L Cryns
Mar 27, 2004·Physiological Reviews·Jesus AvilaFelix Hernandez
Jun 15, 2004·Neurobiology of Disease·Robert SimanVictoria L Roberts
Nov 2, 2004·Journal of Neural Transmission·C-X GongK Iqbal
Mar 8, 2005·Journal of Alzheimer's Disease : JAD·Luisa FasuloAntonino Cattaneo
Apr 16, 2005·The Journal of Biological Chemistry·Della C DavidJürgen Götz
Jun 3, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·So-Young Park, Adriana Ferreira
Sep 24, 2005·Journal of Cell Science·Michelle A UttonDiane P Hanger
Nov 25, 2005·Journal of Cell Science·Peter J Hollenbeck, William M Saxton
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Giuseppina AmadoroNadia Canu
Jun 17, 2006·The EMBO Journal·Naotada IshiharaKatsuyoshi Mihara
Aug 8, 2006·Human Molecular Genetics·Ebrahim Abdul ShukkurKazuhiro Yamakawa
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·Gail V W Johnson
Jul 20, 2007·PLoS Biology·Guido Kroemer, Klas Blomgren
Dec 7, 2007·The European Journal of Neuroscience·Fei LiuCheng-Xin Gong
May 31, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Inmaculada Cuchillo-IbanezDiane P Hanger
Aug 9, 2008·Journal of Alzheimer's Disease : JAD·Francisco García-SierraGustavo Basurto-Islas
Dec 17, 2008·Neuron·Mark P MattsonAiwu Cheng
Mar 17, 2009·Molecular Neurodegeneration·Tania F Gendron, Leonard Petrucelli
May 30, 2009·Molecular Biology of the Cell·Zhiyin SongDavid C Chan
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Sébastien PerreaultNicole Leclerc
Jul 21, 2009·Biochimica Et Biophysica Acta·Heng Du, Shirley ShiDu Yan
Nov 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Virginie RheinAnne Eckert
Nov 12, 2009·Expert Review of Neurotherapeutics·Diane P HangerWendy Noble
Mar 11, 2010·Molecular Neurobiology·Anne EckertJürgen Götz

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Citations

Jan 4, 2019·Current Protein & Peptide Science·Botond PenkeLívia Fülöp
Jan 25, 2019·British Journal of Pharmacology·Judit M Perez Ortiz, Russell H Swerdlow
Dec 11, 2019·Current Alzheimer Research·Aston J WuKing-Ho Cheung
Sep 5, 2020·International Journal of Molecular Sciences·Leonora SzaboAmandine Grimm
Jun 13, 2020·Cellular and Molecular Neurobiology·Nalini Vijay Gorantla, Subashchandrabose Chinnathambi
Oct 20, 2020·Frontiers in Molecular Neuroscience·Klara ZubčićMaja Jazvinšćak Jembrek
Jan 15, 2021·Biomedicines·Simon M BellHeather Mortiboys
Feb 1, 2021·Neurobiology of Disease·Jennifer NgolabRobert A Rissman
Jan 22, 2021·Nature Communications·Gee Euhn ChoiHo Jae Han
Feb 2, 2020·Medical Hypotheses·Annette Offringa-Hup
Mar 21, 2021·Seminars in Cell & Developmental Biology·Jyung Mean Son, Changhan Lee
Jun 25, 2019·American Journal of Human Genetics·Marija Dulovic-MahlowKatja Lohmann
Apr 4, 2021·International Journal of Molecular Sciences·Mehdi EshraghiSaeid Ghavami
Apr 6, 2021·Frontiers in Molecular Neuroscience·Rebecca L MuellerNicholas M Kanaan
Apr 28, 2021·Molecular Neurodegeneration·Tatsuhiro TeradaPedro Rosa-Neto
May 26, 2020·Current Neuropharmacology·Rodrigo A Quntanilla, Carola Tapia-Monsalves
Jun 12, 2021·Annals of the New York Academy of Sciences·Zahra JafariMajid H Mohajerani
Nov 11, 2021·Molecular Neurobiology·Tiziana PetrozzielloGhazaleh Sadri-Vakili
Jan 11, 2022·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tatsuhiro TeradaPedro Rosa-Neto
Jan 13, 2022·Neural Regeneration Research·Angie K TorresCheril Tapia-Rojas

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Methods Mentioned

BETA
antisense oligonucleotide
GTPase
GTPases
ubiquitination
transfection

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