Contribution of the endocervical Cytobrush sample to the diagnosis of cervical lesions

Acta Cytologica
R Luzzatto, M E Boon

Abstract

To compare the contribution of endocervical Cytobrush samples to wooden spatula samples in the detection of cervical preneoplastic lesions. Cytobrush sampling was performed on 56,120 women in conjunction with ectocervical spatula sampling, resulting in two smears per patient. Almost all women with cytologic diagnoses of high grade squamous intraepithelial lesions (CIN 3) or higher were biopsied. For the 221 CIN 3, the contribution of the endocervical sample was clearly more efficient, with diagnosis achieved on 98% of the endocervical samples and on 62% of the ectocervical ones. In the 674 low grade squamous epithelial lesion cases, the endocervical samples were diagnostic in 79% of cases and the ectocervical smears in 64%. Thus, endocervical sampling proved to be superior in the recognition of precancerous lesions. In 93% of the 53 squamous carcinomas, cancer cells were found in both ectocervical and endocervical samples and in 7%, exclusively in endocervical smears. In 76% of the 21 adenocarcinomas, both samples were positive, and in 23% only the endocervical sample contained cancer cells. The Cytobrush samples were more efficient in the detection of intraepithelial neoplastic lesions, suggesting that most of them originate i...Continue Reading

Citations

Jul 25, 2000·Diagnostic Cytopathology·S M Selvaggi, B J Guidos
Nov 26, 1999·Clinical Obstetrics and Gynecology·G F Sawaya, A E Washington
Oct 20, 2006·Journal of Lower Genital Tract Disease·D Kurtycz
May 11, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Z EftekharP Rahimi-Moghaddam
Apr 11, 2006·Diagnostic Cytopathology·John A Maksem
Oct 1, 1996·Cytopathology : Official Journal of the British Society for Clinical Cytology·V Wadehra, K Sankar

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