Contribution of the MDRD equation and of cystatin C for renal function estimates in cancer patients.

Medical Oncology
Sophie Séronie-VivienEtienne Chatelut

Abstract

Serum creatinine (SCr) and Cockcroft-Gault creatinine clearance (CG CrCL) are used to estimate glomerular filtration rate (GFR). Other markers have been proposed including serum cystatin C (cysC) and the Modification of Diet in Renal Disease (MDRD) study equation. We have compared the diagnostic performances of SCr, cysC, CG CrCL, and the MDRD equation in 144 cancer patients. For reference we used either the measured or the predicted carboplatin clearance, which is around the GFR + 25 mL/min. CysC was more sensitive than SCr (70.1% vs 13.4%) but was not very specific (61% for a cut-off = 0.95 mL). CysC values were higher in 40 cancer patients vs 40 healthy controls with a similar and normal mean CG CrCL (1.08 vs 0.71 mg/L; p < 0.001). CG and the MDRD equations gave similar values for Pearson's coefficient, ROC-plot AUC, and precision, except for patients with poor general status, where the MDRD equation was better (MAPE: 12.4% vs 19.6%, p < 0.001; R: 0.908 vs 0.813). In cancer patients, cysC is a more sensitive indicator of the glomerular filtration rate than SCr, but its diagnostic performance is lower than for CG CrCL. There may be no advantage in replacing the CG equation by the MDRD equation except for patients with severe ...Continue Reading

Citations

Apr 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sangeeta Hingorani
Mar 20, 2012·International Journal of Hematology·Holger NückelPeter Liebisch
Nov 23, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N L AinsworthH M Earl
Nov 1, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Sophie Séronie-VivienUNKNOWN SFBC "Biology of renal function and renal failure" working group
Apr 18, 2009·The Journal of Urology·Hyung L KimGregory E Wilding
Nov 11, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·L H BarracloughS E Davidson
Aug 4, 2007·Acta Clinica Belgica·N Lameire
Dec 5, 2014·Asia-Pacific Journal of Clinical Oncology·Janice S C Chew-HarrisZoltan H Endre
Nov 14, 2008·Current Opinion in Critical Care·Norbert LameireRaymond Vanholder
Sep 1, 2012·British Journal of Cancer·A J CraigA Britten
Feb 27, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Sangeeta HingoraniGeorge J Schwartz
Jul 19, 2012·Oncology Letters·Gen OharaHiroaki Satoh
Jul 27, 2011·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Ivana Cláudia GabrielGianna Mastroianni Kirsztajn
May 10, 2021·Transplantation and Cellular Therapy·Russell Whelan, Sangeeta Hingorani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
E D PoggioP M Hall
Annals of Oncology : Official Journal of the European Society for Medical Oncology
M KleberM Engelhardt
© 2022 Meta ULC. All rights reserved