Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats

Neuroscience Letters
Ryuji FukumoriTakao Kubo

Abstract

We previously demonstrated involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. In this study, neuronal perikarya in the medial amygdaloid nucleus of 4-week-old spontaneously hypertensive rats (SHR) were selectively destroyed with ibotenic acid. Bilateral lesions of the medial amygdaloid nucleus attenuated the development of hypertension in SHR. Body weight gain was not different between lesioned and sham-lesioned SHR throughout the experimental periods. These data suggest that neurons in the medial amygdaloid nucleus may be involved in the development of hypertension in SHR.

References

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Citations

Jun 10, 2010·Clinical and Experimental Pharmacology & Physiology·Pamela J Davern, Geoffrey A Head
Jan 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J GianarosAhmad R Hariri
Apr 20, 2012·Canadian Journal of Physiology and Pharmacology·Helinton NeckelAlberto A Rasia-Filho
Nov 17, 2009·Journal of Neuroendocrinology·M B SolomonJ P Herman
Mar 10, 2015·Physiology & Behavior·Daniela Oliveira de AlmeidaJosmara Bartolomei Fregoneze
Apr 10, 2010·American Journal of Hypertension·Pamela J DavernGeoffrey A Head
Nov 27, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E QuagliottoA A Rasia-Filho
Nov 5, 2019·Frontiers in Physiology·Kristy L JacksonFrancine Z Marques
Aug 8, 2021·British Journal of Pharmacology·Hamdi A JamaFrancine Z Marques

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