PMID: 8595613Nov 1, 1995Paper

Contribution of the nitric oxide-guanylyl cyclase system to circadian regulation of blood pressure in normotensive Wistar-Kyoto rats

Cardiovascular Research
K WitteB Lemmer

Abstract

The study was performed in order to elucidate whether or not the nitric oxide-guanylyl cyclase system is involved in the circadian regulation of blood pressure. Basal and sodium nitroprusside-stimulated guanylyl cyclase activity was studied in vitro in aortic tissue from normotensive Wistar-Kyoto rats sacrificed at 7 circadian times. Effects of the nitric oxide synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) on blood pressure and heart rate of rats were measured telemetrically after acute injection of L-NAME either in the morning or in the evening as well as after chronic application in drinking water. Guanylyl cyclase activity exhibited significant circadian rhythmicity under basal conditions and after stimulation by sodium nitroprusside 10 microM. Peaks in cGMP formation were observed in the daily resting period, i.e. the period of low blood pressure in rats. Acute application of L-NAME dose-dependently increased blood pressure; effects were more pronounced after injection in the morning than in the evening, leading to an inverse blood pressure profile after the highest dose (30 mg/kg i.p.). Chronic treatment with L-NAME resulted in a dose-dependent upward shift of the control blood pressure profile. Only at...Continue Reading

Citations

Nov 23, 2013·Journal of Molecular and Cellular Cardiology·M DenniffGlenn C Rodrigo
Nov 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael ObstVolkmar Gross
Aug 15, 2009·Journal of Applied Physiology·R Daniel Rudic, David J Fulton
Apr 1, 2003·The Journal of Physiology·Bruce N Van VlietJean-Pierre Montani
Apr 28, 2004·Experimental Physiology·Tracey J Staughton, Peter D Weinberg
Oct 27, 2005·Regulatory Peptides·Marisa da Silva LemosRobson Augusto Souza Dos Santos
Aug 14, 1999·Journal of Biological Rhythms·I V ZhdanovaJ A Taylor
Mar 3, 2007·Journal of Human Hypertension·O OrmezzanoJ-P Baguet
Nov 14, 1997·Chronobiology International·K WitteB Lemmer
Jan 17, 2020·Acta Physiologica·Zahra BahadoranAsghar Ghasemi
Aug 14, 2020·Brain Structure & Function·Martin A Fuentes-CanoPilar Durán

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