PMID: 8586822Sep 1, 1995Paper

Contribution of the sympathetic nervous system to salt-sensitivity in lifetime captopril-treated spontaneously hypertensive rats

Journal of Hypertension
J M WyssS Roysommuti

Abstract

To test the hypothesis that, in lifetime captopril-treated spontaneously hypertensive rats (SHR), the sympathetic nervous system contributes importantly to the hypertensive effect of dietary sodium chloride supplementation. Male SHR (aged 6 weeks) that had been treated from conception onward with either captopril or vehicle remained on a basal sodium chloride diet or were fed a high sodium chloride diet. After 2 weeks, the rats were subjected to ganglionic blockade and 2 days later, an infusion of clonidine. Lifetime captopril treatment significantly lowered mean arterial pressure in both groups. Intravenous infusion of the ganglionic blocker hexamethonium resulted in a rapid decline in MAP that eliminated the dietary sodium chloride-induced increase in MAP in both groups. Infusion of the central nervous system alpha2-adrenergic receptor agonist clonidine also resulted in a greater reduction in MAP in both groups of SHR that were fed the high (compared with the basal) sodium chloride diet. In both lifetime captopril-treated and control SHR, the sympathetic nervous system contributes to the pressor effects of a high sodium chloride diet.

Citations

Oct 17, 2012·Amino Acids·Sanya Roysommuti, J Michael Wyss
Jun 9, 2006·Kidney International·M S MozaffariS W Schaffer
Jun 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fiona D McBrydeCarolyn J Barrett
Jan 14, 2004·Canadian Journal of Physiology and Pharmacology·Sanya RoysommutiJ Michael Wyss

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