PMID: 8874781Jul 1, 1996Paper

Contribution of the ventricles and the atrial appendages to the elevation of plasma atrial natriuretic factor (ANF) during pacing-induced heart failure in conscious dogs

Basic Research in Cardiology
W ShenT H Hintze

Abstract

The goal of our study was to determine whether the elevation in plasma ANF was produced by the atrial appendages or ventricular tissue during pacing-induced heart failure in chronically instrumented conscious dogs (sham) or dogs with bilateral atrial appendectomy. Acute volume expansion caused a significant elevation of plasma ANF from 80 +/- 8 to 149 +/- 26 pg/ml (p < 0.01) in sham dogs, but caused no significant change from 67 +/- 7 to 84 +/- 8 pg/ml in atrial appendectomized dogs. There were increases in left ventricular end-diastolic pressure (LVEDP) and left atrial pressure (LAP) in both groups of dogs. After rapid left ventricular pacing (210-240 beats/min) for 4 weeks to induce heart failure, dogs in both groups had tachycardia, elevated LVEDP and higher LAP. Plasma ANF was increased by 250% to 283 +/- 64 pg/ml (p < 0.01) in sham dogs, and only 40% to 94 +/- 15 pg/ml (p > 0.05) in atrial appendectomized dogs. In response to volume expansion, there were further increases in LVEDP and LAP in both groups of dogs, but plasma ANF was not elevated (288 +/- 39 pg/ml) in sham dogs and only slightly increased (132 +/- 7 pg/ml) in atrial appendectomized dogs. Our results suggest that, during pacing-induced heart failure, the atria...Continue Reading

References

Sep 1, 1990·Circulation Research·T H HintzeG A Zeballos
Jan 1, 1989·The Journal of Clinical Investigation·Y SaitoT Yamada
Feb 1, 1989·Journal of the American College of Cardiology·P S DouglasN Reichek
May 1, 1987·The Journal of Clinical Investigation·Y F WeiP Needleman
Jan 1, 1985·Endocrine Reviews·M Cantin, J Genest
Jun 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C ChapeauM Cantin
Nov 1, 1974·The American Journal of Cardiology·K L GouldJ W Kennedy
Jun 1, 1971·American Heart Journal·H N ColemanE Braunwald

Citations

Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Robert M GillWeiqun Shen
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Weiqun ShenMitchell I Steinberg
Dec 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Aldo ClericoMichele Emdin

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