PMID: 8938102Dec 1, 1996Paper

Contribution of Thy-1-CD4+ T cells to the disorganization of lymphoid follicles in retrovirus-induced immunodeficiency syndrome, MAIDS

Clinical Immunology and Immunopathology
A MasudaT Kasajima

Abstract

The destruction of the lymphoid follicle (LF) and of the follicular dendritic cell network in the secondary lymphoid organs are major pathological features in murine acquired immunodeficiency syndrome (MAIDS). These pathological changes are associated with functional deficiency of lymphocytes. However, the mechanisms involved have not been established. In MAIDS-susceptible C57BL/6 (B6) mice, the destruction of the LF occurred as early as 2-3 weeks after the infection by LP-BM5 murine leukemia virus (MuLV) and was accompanied by the intrafollicular infiltration of T cells of an unusual phenotype, Thy-1-CD4+. B6 mice, which Thy-1+ T cells had been depleted by the repeated inoculation with monoclonal antibody to Thy-1 antigen, developed LF destruction after infection similar to the control B6 mice. The LP-BM5 MuLV-infected C57BL/6-nu/nu (B6-nu/nu) mice, otherwise resistant to MAIDS induction, also developed these abnormalities following the adoptive transfer of highly purified Thy-1-CD4+ T cells obtained from MAIDS mice. Thus, the production of Thy-1-CD4+ T cells and their infiltration into LF are thought to be involved in triggering the LF destruction. However, the cytolysis of follicular components by activated CD8+ T cells or b...Continue Reading

Citations

Aug 15, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·Y SurugaM Baba
Apr 1, 1997·Immunological Reviews·G F BurtonA K Szakal
Feb 24, 2016·Journal of Immunology Research·Adi Essam ZareiElrashdy M Redwan
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S RahmouniM Moutschen

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