PMID: 7528353Aug 1, 1994Paper

Contribution of transplantations to the understanding of the role of the PLP gene

Neurochemical Research
F LachapelleN Baumann

Abstract

We present an overview of the results obtained in a cross-transplantation system using respectively controls, jimpy (jp), and shiverer mutant mice as donors and recipients. Homochronic transplantations (O days into O days) demonstrated that jp environment is non-toxic for non-jp cells and that, contrary to in vitro, jp oligodendrocytes phenotype cannot be modified by environmental factors at this age. Transplantations of embryonic fragments into the newborn brain demonstrated that in contrast to oligodendrocyte precursors contained in fragments of newborn tissue, jimpy embryonic stem cells are sensitive to environmental factors able to modulate the proportion of surviving oligodendrocytes. In addition, these series evidenced a disjunction between the surviving and the myelinating capacity of jp cells demonstrating a pleiotropic effect of the jp mutation on oligodendrocyte biology. Results are discussed with regards to the recent molecular biological finding on the role of the DM20/PLP gene.

References

Jan 1, 1990·Developmental Neuroscience·M K VermeeschJ A Benjamins
Jan 1, 1991·Glia·J E Goldman, P J Vaysse
Jun 1, 1991·Journal of Neuroscience Research·F LachapelleM Gumpel
Jan 1, 1990·Developmental Neuroscience·P E KnappR P Skoff
Feb 1, 1986·The Journal of Cell Biology·M Dubois-DalcqR A Lazzarini
Aug 1, 1988·Journal of Neurocytology·M S Ghandour, R P Skoff
Nov 15, 1988·The Journal of Comparative Neurology·S M LeVine, J E Goldman
Jan 1, 1987·Annals of the New York Academy of Sciences·M GumpelN Baumann
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K A NaveR J Milner
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Oct 27, 1980·Brain Research·S Billings-GagliardiM K Wolf
Jan 1, 1986·Neurochemistry International·T V WaehneldtG Jeserich

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Citations

Mar 16, 2011·Archives of Neurology·Steven A Goldman
May 26, 1998·Brain Research. Brain Research Reviews·J M VelaB Castellano
Jul 18, 2008·Human Molecular Genetics·Steven A GoldmanMartha S Windrem
May 14, 2016·Experimental Neurology·M Joana Osorio, Steven A Goldman

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