Contribution of type IV pili to the virulence of Aeromonas salmonicida subsp. salmonicida in Atlantic salmon (Salmo salar L.).

Infection and Immunity
Jessica BoydMichael Reith

Abstract

Aeromonas salmonicida subsp. salmonicida, a bacterial pathogen of Atlantic salmon, has no visible pili, yet its genome contains genes for three type IV pilus systems. One system, Tap, is similar to the Pseudomonas aeruginosa Pil system, and a second, Flp, resembles the Actinobacillus actinomycetemcomitans Flp pilus, while the third has homology to the mannose-sensitive hemagglutinin pilus of Vibrio cholerae. The latter system is likely nonfunctional since eight genes, including the gene encoding the main pilin subunit, are deleted compared with the orthologous V. cholerae locus. The first two systems were characterized to investigate their expression and role in pathogenesis. The pili of A. salmonicida subsp. salmonicida were imaged using atomic force microscopy and Tap- and Flp-overexpressing strains. The Tap pili appeared to be polar, while the Flp pili appeared to be peritrichous. Strains deficient in tap and/or flp were used in live bacterial challenges of Atlantic salmon, which showed that the Tap pilus made a moderate contribution to virulence, while the Flp pilus made little or no contribution. Delivery of the tap mutant by immersion resulted in reduced cumulative morbidity compared with the cumulative morbidity observed...Continue Reading

References

Nov 5, 1997·Microbial Pathogenesis·T C BarnettK Sanderson
Jul 31, 1998·Diseases of Aquatic Organisms·A I FernandezA E Ellis
Mar 26, 1999·Microbial Pathogenesis·T C Barnett, S M Kirov
Feb 19, 2000·Current Opinion in Microbiology·F G SauerS J Hultgren
Jul 27, 2002·Annual Review of Microbiology·John S Mattick
Sep 21, 2002·Diseases of Aquatic Organisms·Cynthia L MasadaMark S Strom
Oct 11, 2002·Journal of Bacteriology·Sarah E BurrJoachim Frey
Apr 30, 2003·Nature Genetics·Paul J PlanetDavid H Figurski
Jan 22, 2004·FEMS Immunology and Medical Microbiology·Christopher D BaylissE Richard Moxon
Apr 22, 2004·Nature Reviews. Microbiology·Lisa CraigJohn A Tainer
Oct 22, 2004·Contributions to Microbiology·Ann-Beth JonsonMikael Rhen
Feb 25, 2006·Cell·Javier Pizarro-Cerdá, Pascale Cossart
May 6, 2006·Science·Gilles DemersMarie Bédard
Jun 22, 2006·Journal of Bacteriology·Sophie de BentzmannAlain Filloux

❮ Previous
Next ❯

Citations

Sep 4, 2013·Applied Microbiology and Biotechnology·Xue GaoGuo-Qiang Chen
Feb 9, 2012·Infection and Immunity·Nahal HadiJonathan G Shaw
Dec 4, 2012·Microbiology and Molecular Biology Reviews : MMBR·Carmen L GiltnerLori L Burrows
Jul 25, 2009·BMC Genomics·Jianying GuYufeng Wang
Feb 15, 2013·Standards in Genomic Sciences·Michael T LeonardEric W Triplett
Jan 1, 2012·ISRN Microbiology·J M Tomás
Oct 4, 2012·Biochimica Et Biophysica Acta·Elke UribeK Vanya Ewart
Feb 22, 2011·Microbial Pathogenesis·Hege Smith TunsjøTrine M L'abée-Lund
Jan 12, 2013·Journal of Fish Diseases·R Beaz-Hidalgo, M J Figueras
Oct 4, 2014·Microbial Pathogenesis·Christian KarlsenHenning Sørum
Jan 7, 2014·Journal of Microbiological Methods·Stéphanie Dallaire-DufresneSteve J Charette
Feb 7, 2017·Frontiers in Microbiology·Emilie Talagrand-ReboulBrigitte Lamy
Nov 11, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Karoline de C PredigerCyntia M T Fadel-Picheth
Feb 9, 2021·Frontiers in Veterinary Science·Baotun WangYoulu Su
Mar 9, 2021·Frontiers in Immunology·Juan Pablo PontigoAlejandro J Yáñez
Mar 9, 2019·Microbial Pathogenesis·Rafael Bastos Gonçalves PessoaLuana Cassandra Breitenbach Barroso Coelho
Jul 17, 2020·ACS Applied Materials & Interfaces·Thomas D YoungPaul S Weiss

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.