Contribution of uremic dysbiosis to insulin resistance and sarcopenia.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Kiyotaka UchiyamaHiroshi Itoh

Abstract

Chronic kidney disease (CKD) leads to insulin resistance (IR) and sarcopenia, which are associated with a high mortality risk in CKD patients; however, their pathophysiologies remain unclear. Recently, alterations in gut microbiota have been reported to be associated with CKD. We aimed to determine whether uremic dysbiosis contributes to CKD-associated IR and sarcopenia. CKD was induced in specific pathogen-free mice via an adenine-containing diet; control animals were fed a normal diet. Fecal microbiota transplantation (FMT) was performed by oral gavage in healthy germ-free mice using cecal bacterial samples obtained from either control mice (control-FMT) or CKD mice (CKD-FMT). Vehicle mice were gavaged with sterile phosphate-buffered saline. Two weeks after inoculation, mice phenotypes, including IR and sarcopenia, were evaluated. IR and sarcopenia were evident in CKD mice compared with control mice. These features were reproduced in CKD-FMT mice compared with control-FMT and vehicle mice with attenuated insulin-induced signal transduction and mitochondrial dysfunction in skeletal muscles. Intestinal tight junction protein expression and adipocyte sizes were lower in CKD-FMT mice than in control-FMT mice. Furthermore, CKD-FMT...Continue Reading

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Citations

Dec 2, 2020·Toxins·Christophe BarbaLaetitia Koppe
Dec 2, 2020·Microorganisms·Ryota IkeeSawako Fukazawa
Mar 22, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chenyu Li, Hans-Joachim Anders
Aug 1, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kiyotaka UchiyamaHiroshi Itoh
Sep 24, 2021·Journal of Cachexia, Sarcopenia and Muscle·Kiyotaka UchiyamaHiroshi Itoh

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