Contribution of vaccine-induced immunity toward either the HA or the NA component of influenza viruses limits secondary bacterial complications.

Journal of Virology
Victor C HuberJonathan A McCullers

Abstract

Secondary bacterial infections contribute to morbidity and mortality from influenza. Vaccine effectiveness is typically assessed using prevention of influenza, not secondary infections, as an endpoint. We vaccinated mice with formalin-inactivated influenza virus vaccine preparations containing disparate HA and NA proteins and demonstrated an ability to induce the appropriate anti-HA and anti-NA immune profiles. Protection from both primary viral and secondary bacterial infection was demonstrated with vaccine-induced immunity directed toward either the HA or the NA. This finding suggests that immunity toward the NA component of the virion is desirable and should be considered in generation of influenza vaccines.

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Citations

Oct 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Diana TasherEli Somekh
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Keith WanzeckJonathan A McCullers
Sep 3, 2011·Influenza and Other Respiratory Viruses·Kevin T CwachVictor C Huber
Mar 23, 2012·Reviews in Medical Virology·Glendie MarcelinRichard J Webby
Sep 27, 2013·Influenza and Other Respiratory Viruses·Carol JosephNahoko Shindo
Apr 17, 2015·FEMS Microbiology Letters·Jaelle C BrealeyKeith J Chappell
Jan 19, 2012·Human Vaccines & Immunotherapeutics·Jonathan A McCullers, Victor C Huber
Nov 26, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shishir K GuptaShailendra K Gupta
Jul 4, 2013·Pathogens and Disease·Eva Böttcher-FriebertshäuserWolfgang Garten
Sep 8, 2015·Vaccines·Matthew R SandbulteJames A Roth
Nov 18, 2017·Viral Immunology·Amber M Smith, Victor C Huber
Jun 28, 2018·Future Microbiology·Seung Han Seon, Dong-Kwon Rhee
Sep 14, 2012·Expert Review of Respiratory Medicine·David Paul MooreShabir Ahmed Madhi
Aug 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dennis W Metzger, Keer Sun
Dec 8, 2017·International Journal of Molecular Sciences·Daniela MachadoGlaucia Paranhos-Baccalà
Sep 12, 2014·Expert Review of Vaccines·Ioanna ChristopoulouXavier Saelens
Apr 9, 2021·Frontiers in Cellular and Infection Microbiology·Vicky SenderBirgitta Henriques-Normark
Jun 28, 2021·Medicina intensiva·N J ProañosUNKNOWN on behalf GETGAG SEMICYUC Working Group

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