PMID: 9178376Apr 1, 1997Paper

Contribution of vagal afferents to breathing pattern in rats with lung fibrosis

Respiration Physiology
J K MansoorE S Schelegle

Abstract

In anesthestized male Wistar rats with bleomycin-induced lung fibrosis we examined the influence of lung vagal non-myelinated and myelinated afferents in setting breathing pattern. Fourteen days after intratracheal instillation of bleomycin, lung compliance, total lung capacity (TLC) and inspiratory capacity were reduced while functional residual capacity and residual volume were increased. Baseline tidal volume (VT) was decreased and frequency (fR) increased in the bleomycin treated rats compared with controls. Selective vagal C-fiber blockade did not affect fR or VT in any group. Vagotomy resulted in an increase in VT and decrease in fR in both groups with the percent increase in VT/TLC and decrease in fR being significantly greater in the bleomycin rats compared with controls. Vagotomy also attenuated the significantly elevated PCO2 in the bleomycin treated rats suggesting that bleomycin-induced alterations in breathing pattern contribute to blood gas abnormalities. We conclude that vagal myelinated afferents contribute to the rapid shallow breathing in bleomycin treated rats.

References

Apr 1, 1986·Respiration Physiology·T E PisarriJ C Coleridge
May 1, 1987·Respiration Physiology·J YuH M Coleridge
Apr 1, 1988·Respiration Physiology·A JonzonH M Coleridge
Jan 1, 1986·Annals of the New York Academy of Sciences·G RenziA E Grassino
Feb 1, 1987·Respiration Physiology·R D HamiltonA Guz
Jan 1, 1970·Pflügers Archiv : European journal of physiology·T Schmidt, H H Wellhöner

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Citations

Mar 10, 2001·Respiration Physiology·E S Schelegle, J F Green
Apr 20, 2001·Respiration Physiology·E S SchelegleA T Chen
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·M L CarlJ F Green
Apr 25, 2012·Respiratory Physiology & Neurobiology·Edward S Schelegle, William F Walby
Dec 13, 2005·Respiratory Physiology & Neurobiology·Michael J Carr, Lu-Yuan Lee
Oct 15, 2011·Respiration; International Review of Thoracic Diseases·Phillipa L MiltonRebecca Lim
Dec 21, 2002·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Edward S Schelegle
Jun 14, 2000·Journal of Basic and Clinical Physiology and Pharmacology·E S SchelegleC Y Loh
Nov 22, 2001·Journal of Applied Physiology·F J GolderD C Bolser
Apr 15, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christine EggerNicolau Beckmann

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