Contribution to Accurate Spherical Gold Nanoparticle Size Determination by Single-Particle Inductively Coupled Mass Spectrometry: A Comparison with Small-Angle X-ray Scattering

Analytical Chemistry
Valérie GeertsenOlivier Taché

Abstract

Small-angle X-ray scattering spectroscopy (SAXS) is the method of choice for nanoparticle diameter and concentration determination. On the one hand, it is metrologically traceable for spherical nanoparticle mean diameter determination and does not require any sample preparation or calibration. On the other hand, single-particle inductively coupled mass spectrometry (SPICPMS) is still under development and requires involved process clarification and accuracy improvement. The strategy of this study is the comparison of the two techniques to study comprehensively SPICPMS performance and observe phenomena otherwise hidden. Six spherical gold nanoparticle suspensions distributed over a large size range (30, 50, 60, 80,100, and 150 nm) are studied as calibration points. Potential matrix effects are eliminated by stabilizing nanoparticles with chitosan in HCl. Chitosan encapsulates nanoparticles, stabilizes their dispersion, and protects them from dissolution. Detection counting/analogue threshold and timeout appear as the relevant parameters for transient signals. They show an influence not only on mean signal but also on signal distribution. The detection tuning proposed allows to linearly calibrate the nanoparticle distribution sig...Continue Reading

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Apr 4, 2015·Marine Drugs·Emilia Szymańska, Katarzyna Winnicka
Jun 20, 2015·Journal of Applied Crystallography·I BresslerA F Thünemann
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Citations

May 6, 2019·Electrophoresis·Siyao Liu, Michael Lämmerhofer
Jun 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marine Le GoasJean-Philippe Renault
Jul 23, 2020·Lab on a Chip·Tobias LangeFlorent Malloggi
Jun 24, 2021·Analytical Methods : Advancing Methods and Applications·Eduardo BoleaFrancisco Laborda
Aug 9, 2021·Talanta·Najoua Bouzakher-GhomrasniCarine Chivas-Joly

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