Contributions of cellular electrophysiology to the understanding of the electrocardiogram

Experientia
B Surawicz

Abstract

The understanding of cardiac action potential and membrane currents has broadened the theoretical foundation and enhanced the clinical usefulness of the electrocardiogram. An improved understanding of the morphology of the electrocardiographic waveform has resulted from: correlations between Vmax of depolarization and QRS complex, plateau of the ventricular action potential and S-T segment, terminal repolarization and T-wave, from definitions of action potential differences responsible for the T-wave, and recordings of action potential alternans. Cellular electrophysiology has contributed to the understanding of certain mechanisms of cardiac standstill. Many disturbances of conduction and refractoriness associated with ventricular arrhythmias can be attributed to the following derangements at the cellular level: slowing of terminal repolarization, development of diastolic depolarization in fibers with stable resting membrane potential, after-depolarizations, currents of injury resulting from non-uniform polarization, increased dispersion of action potential durations, and co-existence of slow conduction and short premature action potentials.

References

Apr 1, 1975·American Heart Journal·G AutenriethC S Kuo
Jun 1, 1967·The American Journal of Physiology·B SurawiczA Ponce-Zumino
Aug 1, 1968·Circulation·R ShabetaiW Hammill
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·P Heistracher
Dec 1, 1972·The American Journal of Cardiology·F S DaoudL S Gettes
Jun 1, 1967·American Heart Journal·B Surawicz
Jul 1, 1968·The American Journal of Physiology·J R LogicB Surawicz
Oct 1, 1965·Circulation Research·M Vassalle, B F Hoffman
Oct 1, 1967·Circulation Research·D H SingerB F Hoffman
Sep 1, 1983·Cardiovascular Research·R J Hariman, C M Chen
Dec 1, 1962·The American Journal of Physiology·L S GETTESJ C SHIUE
Apr 1, 1963·Circulation Research·B SURAWICZ, L S GETTES
Sep 1, 1951·The Journal of Physiology·M H DRAPER, S WEIDMANN
Feb 1, 1950·Circulation·L A WOODBURYH H HECHT

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Citations

Jan 17, 2009·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Guy SalamaBarry London
Dec 5, 2003·Trends in Pharmacological Sciences·Luiz BelardinelliMarc A Vos
Jul 1, 1999·The Journal of Cardiovascular Nursing·V M Vizgirda
Jun 7, 2005·Expert Opinion on Drug Safety·Martin Traebert, Berengere Dumotier
Feb 1, 1990·International Journal of Cardiology·N J Severs
Aug 9, 2003·Journal of the American College of Cardiology·Gan-Xin YanPeter R Kowey

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