Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins

Progress in Lipid Research
Hiroyuki SaitoMichael C Phillips

Abstract

Exchangeable apolipoproteins function in lipid transport as structural components of lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. Recent findings with apoA-I and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related. Characteristically, these proteins contain a series of proline-punctuated, 11- or 22-amino acid, amphipathic alpha-helical repeats that can adopt a helix bundle conformation in the lipid-free state. The amino- and carboxyl-terminal regions form separate domains with the latter being primarily responsible for lipid binding. Interaction with lipid induces changes in the conformation of the amino-terminal domain leading to alterations in function; for example, opening of the amino-terminal four-helix bundle in apolipoprotein E upon lipid binding is associated with enhanced receptor-binding activity. The concept of a two-domain structure for the larger exchangeable apolipoproteins is providing new molecular insights into how these apolipoproteins interact with lipids and other proteins, such as receptors. The ways in which structural changes induced by lipid interaction modulate the functionality of these a...Continue Reading

References

Jan 22, 1991·Biochemistry·D R BreiterH M Holden
Jan 1, 1990·Proteins·J P SegrestG M Anantharamaiah
Aug 22, 1989·Biochimica Et Biophysica Acta·J A IbdahM C Phillips
Jun 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·M F Dumon, M Clerc
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M S BoguskiJ I Gordon
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H B BrewerK M John
Jul 24, 1974·Biochemical and Biophysical Research Communications·J B SwaneyH A Eder
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
May 17, 1995·Biochimica Et Biophysica Acta·C G Brouillette, G M Anantharamaiah
Jan 1, 1994·Advances in Protein Chemistry·K H Weisgraber
Jan 1, 1994·Advances in Protein Chemistry·J P SegrestG M Anantharamaiah
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·O Gursky, D Atkinson
Sep 1, 1996·Protein Science : a Publication of the Protein Society·O Gursky, D Atkinson
Nov 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K H Weisgraber, R W Mahley
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·W S DavidsonA Jonas
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·D W BorhaniC G Brouillette
May 18, 1999·The Journal of Biological Chemistry·V KoppakaP H Axelsen
Aug 4, 1999·Current Opinion in Lipidology·R W Mahley, Y Huang
Sep 11, 1999·Current Opinion in Lipidology·D L WilliamsG H Rothblat
Nov 5, 1999·The Journal of Biological Chemistry·J P SegrestS C Harvey

❮ Previous
Next ❯

Citations

Apr 14, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kirsty GreenowDipak P Ramji
Sep 15, 2012·Bulletin of Experimental Biology and Medicine·E A Yur'evaA A Dreval
Feb 13, 2009·Biochemistry·David NguyenSissel Lund-Katz
Oct 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Palaniappan Sevugan ChettyMichael C Phillips
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yuan Qi WongMichael D W Griffin
Jun 30, 2012·Proceedings of the National Academy of Sciences of the United States of America·Palaniappan Sevugan ChettyMichael C Phillips
Aug 13, 2011·The Journal of Biological Chemistry·Shobini JayaramanGiorgio Cavigiolio
Aug 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angelo M Scanu, Celina Edelstein
May 14, 2005·Current Opinion in Lipidology·Olga Gursky
May 14, 2005·Current Opinion in Lipidology·W Sean Davidson, R A Gangani D Silva
May 15, 2007·Current Opinion in Lipidology·Kasuen Wong, Robert O Ryan
Nov 2, 2005·Molecular and Cellular Biology·Christopher E EllisRobert L Nussbaum
Dec 19, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Marina CuchelDaniel J Rader
Nov 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Eric T AlexanderMichael C Phillips
Oct 22, 2008·Malaria Journal·Marissa VignaliStanley Fields
Sep 30, 2009·Journal of Lipid Research·Sissel Lund-KatzMichael C Phillips
Mar 26, 2009·Journal of Lipid Research·Eric T AlexanderMichael C Phillips
Jun 3, 2008·Journal of Lipid Research·Michael J ThomasMary G Sorci-Thomas
Nov 20, 2008·Journal of Lipid Research·Godfrey S Getz, Catherine A Reardon
Aug 4, 2009·Future Lipidology·Elena Posse de Chaves, Vasanthy Narayanaswami
Feb 1, 2009·Clinical Lipidology·Mary G Sorci-ThomasMichael J Thomas
Feb 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·A Abdul AjeesH M Krishna Murthy
Oct 5, 2014·Biochimica Et Biophysica Acta·Chiharu MizuguchiHiroyuki Saito
Jan 23, 2016·Frontiers in Pharmacology·Valentin Gogonea
Aug 11, 2015·Proteomics. Clinical Applications·Frances ZenónHoracio Serrano
Oct 30, 2012·Archives of Biochemistry and Biophysics·Tuyen N TranVasanthy Narayanaswami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Biology of Lipids

Lipids are essential in many biological functions, including membrane structure, energy storage, and cell signaling. Find the latest research on the cell biology of lipids here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

Trends in Biochemical Sciences
Danny M HattersK H Weisgraber
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
V NarayanaswamiPaul M M Weers
Proceedings of the National Academy of Sciences of the United States of America
Jianjun WangR O Ryan
© 2022 Meta ULC. All rights reserved