Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis

Schizophrenia Research
Ricardo E CarriónDaniel C Javitt

Abstract

There is a growing recognition that individuals at clinical high risk need intervention for functional impairments, along with emerging psychosis, as the majority of clinical high risk (CHR) individuals show persistent deficits in social and role functioning regardless of transition to psychosis. Recent studies have demonstrated reduced reading ability as a potential cause of functional disability in schizophrenia, related to underlying deficits in generation of mismatch negativity (MMN). The present study extends these findings to subjects at CHR. The sample consisted of 34 CHR individuals and 33 healthy comparison subjects (CNTLs) from the Recognition and Prevention (RAP) Program at the Zucker Hillside Hospital in New York. At baseline, reading measures were collected, along with MMN to pitch, duration, and intensity deviants, and measures of neurocognition, and social and role (academic/work) functioning. CHR subjects showed impairments in reading ability, neurocognition, and MMN generation, relative to CNTLs. Lower-amplitude MMN responses were correlated with worse reading ability, slower processing speed, and poorer social and role functioning. However, when entered into a simultaneous regression, only reduced responses to...Continue Reading

References

Nov 15, 1991·Biological Psychiatry·A M ShelleyN McConaghy
Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·D C JavittJ C Arezzo
Jul 29, 2004·Schizophrenia Bulletin·Martin KnappJudit Simon
Nov 9, 2004·Schizophrenia Research·Michael F Green, Keith H Nuechterlein
Feb 9, 2005·Archives of General Psychiatry·Gregory A Light, David L Braff
Jun 2, 2005·Schizophrenia Research·Daniel Umbricht, Sanya Krljes
Sep 2, 2005·The American Journal of Psychiatry·Gregory A Light, David L Braff
Feb 25, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T KujalaR Näätänen
Mar 28, 2006·Schizophrenia Research·Tara A NiendamTyrone D Cannon
Apr 11, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuki Kawakubo, Kiyoto Kasai
Aug 8, 2006·Schizophrenia Research·Nadine RevheimDaniel C Javitt
Sep 13, 2006·The Journal of Clinical Psychiatry·Michael F Green
Jan 18, 2008·PharmacoEconomics·A George Awad, Lakshmi N P Voruganti
Oct 17, 2009·Schizophrenia Bulletin·Daniel C Javitt
Jan 16, 2010·Biological Psychiatry·Jonathan K WynnMichael F Green
Dec 21, 2010·Biological Psychiatry·Mitja BodatschAnke Brockhaus-Dumke
Apr 19, 2011·The American Journal of Psychiatry·Jean AddingtonRobert Heinssen
May 4, 2011·The American Journal of Psychiatry·Ricardo E CarriónBarbara A Cornblatt
Oct 26, 2011·Schizophrenia Research·Madiha ShaikhElvira Bramon
Nov 15, 2011·Schizophrenia Bulletin·Barbara A CornblattTodd Lencz
Sep 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gregory A Light, Risto Näätänen
Sep 6, 2013·JAMA Psychiatry·Ricardo E CarriónBarbara A Cornblatt
Oct 29, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seung-Hwan LeeChang-Gyu Kim

❮ Previous
Next ❯

Citations

Feb 28, 2015·Annals of the New York Academy of Sciences·Daniel C Javitt
Aug 21, 2015·Nature Reviews. Neuroscience·Daniel C Javitt, Robert A Sweet
Apr 24, 2016·Schizophrenia Bulletin·Danielle McLaughlinBarbara A Cornblatt
Feb 1, 2018·Clinical EEG and Neuroscience·Jennifer R LepockMichael Kiang
Nov 7, 2019·Scientific Reports·Clément DondéDaniel C Javitt
Jun 11, 2020·Psychiatry and Clinical Neurosciences·Naoya OribeMargaret A Niznikiewicz
Feb 9, 2017·Molecular Psychiatry·M LeeD C Javitt
Aug 18, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Migyung LeeDaniel C Javitt
Nov 3, 2020·Schizophrenia Research·Ricardo E CarriónBarbara A Cornblatt
May 22, 2021·Frontiers in Psychiatry·Andrea PerrottelliArmida Mucci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.