Contributions of Feature Binding During Encoding and Functional Connectivity of the Medial Temporal Lobe Structures to Episodic Memory Deficits Across the Prodromal and First-Episode Phases of Schizophrenia

Clinical Psychological Science : a Journal of the Association for Psychological Science
Kristen M HautTyrone D Cannon

Abstract

Patients with and at risk for psychosis may have difficulty using associative strategies to facilitate episodic memory encoding and recall. In parallel studies, patients with first-episode schizophrenia (n = 27) and high psychosis risk (n = 28) compared with control participants (n = 22 and n = 20, respectively) underwent functional MRI during a remember-know memory task. Psychophysiological interaction analyses, using medial temporal lobe (MTL) structures as regions of interest, were conducted to measure functional connectivity patterns supporting successful episodic memory. During encoding, patients with first-episode schizophrenia demonstrated reduced functional coupling between MTL regions and regions involved in stimulus representations, stimulus selection, and cognitive control. Relative to control participants and patients with high psychosis risk who did not convert to psychosis, patients with high psychosis risk who later converted to psychosis also demonstrated reduced connectivity between MTL regions and auditory-verbal and visual-association regions. These results suggest that episodic memory deficits in schizophrenia are related to inefficient recruitment of cortical connections involved in associative memory forma...Continue Reading

References

Jan 1, 1990·Memory & Cognition·J M Gardiner, R I Java
Feb 1, 1994·Archives of General Psychiatry·A J SaykinR C Gur
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Jul 3, 1998·Cerebral Cortex·D N KennedyV S Caviness
Dec 10, 1999·The Psychiatric Quarterly·T J MillerL Davidson
Jan 13, 2000·Archives of General Psychiatry·L A Glantz, D A Lewis
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Oct 16, 2002·Nature Neuroscience·Andrew P YonelinasRobert T Knight
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 4, 2003·Biological Psychiatry·J Daniel RaglandRuben C Gur
Apr 7, 2004·Archives of General Psychiatry·Theo G M van ErpTyrone D Cannon
May 25, 2004·Nature Neuroscience·Scott D Slotnick, Daniel L Schacter
Mar 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew P YonelinasMichael D Rugg
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura L EldridgeBarbara J Knowlton
Aug 12, 2005·Journal of Child and Adolescent Psychopharmacology·Stephanie E MeyerTyrone D Cannon
Dec 6, 2005·Biological Psychiatry·Todd LenczBarbara A Cornblatt
Jan 13, 2006·Acta Psychologica·Nicole M Dudukovic, Barbara J Knowlton
Jul 4, 2006·Biological Psychiatry·Martin LepageSamarthji Lal
Jan 5, 2007·Hippocampus·Joel R QuammeKenneth A Norman
Mar 16, 2007·Psychiatry Research·Daniel H WolfJ Daniel Ragland
Mar 31, 2007·Psychiatry Research·Paul G NestorRobert W McCarley
May 18, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda J Murray, Charan Ranganath
Oct 30, 2007·Schizophrenia Research·Theo G M van ErpTyrone D Cannon
Jan 9, 2008·Archives of General Psychiatry·Tyrone D CannonRobert Heinssen
May 23, 2008·Biological Psychiatry·Charan RanganathJ Daniel Ragland
Oct 8, 2008·Development and Psychopathology·Katherine H KarlsgodtTyrone D Cannon
Jan 9, 2009·Schizophrenia Research·Ian Ellison-Wright, Ed Bullmore
Jan 14, 2009·Schizophrenia Research·Daqiang SunChristos Pantelis
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Susan Whitfield-GabrieliLarry J Seidman
May 5, 2009·The American Journal of Psychiatry·John D RaglandDavid C Glahn
Jul 23, 2009·Psychiatry Research·David LuckMartin Lepage
Jun 10, 2010·Archives of General Psychiatry·Larry J SeidmanUNKNOWN North American Prodrome Longitudinal Study (NAPLS) Group
Dec 8, 2010·Schizophrenia Bulletin·Kristan ArmstrongStephan Heckers
Mar 17, 2011·The American Journal of Psychiatry·Til WykesPál Czobor
May 4, 2011·Archives of General Psychiatry·Andrea MechelliPhilip McGuire
Jul 7, 2011·Journal of the International Neuropsychological Society : JINS·Aaron Bonner-Jackson, Deanna M Barch

❮ Previous
Next ❯

Citations

Feb 26, 2016·NeuroImage. Clinical·S GuimondM Lepage
Oct 24, 2015·Trends in Cognitive Sciences·Tyrone D Cannon
May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Michael F GreenJunghee Lee
Jan 19, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anastasia Diamantopoulou, Joseph A Gogos
Nov 7, 2017·Schizophrenia Bulletin·Junghee LeeMichael F Green
Mar 23, 2017·Frontiers in Psychology·Sarah Eisenacher, Mathias Zink

❮ Previous
Next ❯

Software Mentioned

FMRIB Linear Image Registration Tool
FLIRT
Excel Basic
FILM FMRIB
Prime
SAS
FEAT ( fMRI Expert Analysis Tool )
FMRIB Software Library
FSL
FEAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.