Contributions of high mobility group box protein in experimental and clinical acute lung injury

American Journal of Respiratory and Critical Care Medicine
Hiroshi UenoAkitoshi Ishizaka

Abstract

This study was performed to examine the putative role of high mobility group box (HMGB) protein in the pathogenesis of acute lung injury (ALI). Observations were made (1) in 21 patients who were septic with ALI and 15 patients with normal lung function and (2) in a mouse model 24 hours after intratracheal instillation of lipopolysaccharide (LPS). The concentrations of HMGB1 were increased in plasma and lung epithelial lining fluid of patients with ALI and mice instilled with LPS. LPS-induced ALI was mitigated by anti-HMGB1 antibody. Although this protein was not detected in the plasma of control humans or mice, the concentrations of HMGB1 in lung epithelial lining fluid or in bronchoalveolar lavage fluid were unexpectedly high. The nuclear expression of HMGB1 was apparent in epithelial cells surrounding terminal bronchioles in normal mice, whereas its nuclear and cytoplasmic expression was observed in alveolar macrophages in LPS-instilled mice. Lung instillation of HMGB2 did not cause as much inflammation as HMGB1. Extracellular HMGB1 may play a key role in the pathogenesis of clinical and experimental ALI. However, its expression in normal airways is noteworthy and suggests that it also plays a physiologic role in the lung.

References

Sep 1, 1988·The American Review of Respiratory Disease·J F MurrayM R Flick
Sep 21, 1973·European Journal of Biochemistry·G H GoodwinE W Johns
Sep 1, 1993·The American Review of Respiratory Disease·K P SteinbergL D Hudson
Jul 10, 1999·Science·H WangK J Tracey
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Aug 22, 2000·The Journal of Experimental Medicine·U AnderssonK J Tracey
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E AbrahamK J Tracey
Apr 17, 2001·Shock·H YangK J Tracey
Nov 22, 2001·Journal of Endotoxin Research·C J CzuraK J Tracey
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Sep 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Luis UlloaKevin J Tracey
Oct 18, 2002·Arthritis and Rheumatism·R KokkolaH Erlandsson Harris
Sep 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Akitoshi IshizakaSatoru Hashimoto
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey

❮ Previous
Next ❯

Citations

Jul 11, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Su Jin JeongJune Myung Kim
Mar 7, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Li XuXiaoliang Wang
Apr 18, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xun LiZuo-Jiong Gong
Oct 18, 2007·Intensive Care Medicine·Satoshi HagiwaraTakayuki Noguchi
Feb 26, 2008·Intensive Care Medicine·Sari KarlssonEsko Ruokonen
Jun 17, 2009·Intensive Care Medicine·Satoshi HagiwaraTakayuki Noguchi
Mar 2, 2011·Intensive Care Medicine·Stéphanie Barnay-VerdierVincent Maréchal
Nov 26, 2011·Langenbeck's Archives of Surgery·Takahisa YoshikawaYuko Kitagawa
Mar 28, 2013·Journal of Anesthesia·Satoshi NishiikeHideaki Tsuchida
Aug 27, 2010·Surgery Today·Fumio KimuraMasaru Miyazaki
Oct 12, 2012·Archives of Pharmacal Research·Jong-Sup Bae
Jun 22, 2013·Cytokine & Growth Factor Reviews·Zhongjie SunZhonge Zhang
Nov 5, 2008·Expert Reviews in Molecular Medicine·Haichao WangAndrew E Sama
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
Jan 9, 2008·Antioxidants & Redox Signaling·Sadatomo TasakaAkitoshi Ishizaka
Sep 29, 2007·Critical Care Medicine·Marieke A D van ZoelenTom van der Poll
Nov 23, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yuichiro SakamotoYasuhiro Yamamoto
May 23, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yuichiro SakamotoYasuhiro Yamamoto
Apr 1, 2009·Shock·Haichao WangAndrew E Sama
Nov 28, 2007·Annual Review of Pathology·Kenneth L Rock, Hajime Kono
Jan 25, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Naoko YamakawaKoshi Makita

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

© 2021 Meta ULC. All rights reserved